PEDSnet does research to improve the health and lives of children. We are a large, national community of hospitals and healthcare organizations, researchers and clinicians, and patients and families. This community works together to identify the most important research questions that can reduce children's suffering and support their healthy development. When we do research, our goal is to conduct it as inexpensively and quickly as possible, while engaging all of our stakeholders in the research process along the way. PEDSnet has formed a multi-specialty network that conducts observational research and clinical trials across multiple children's hospital health systems. We are governed by parents and senior leaders in these health systems. PEDSnet has produced reusable and expandable governance, logistical, informatics, regulatory, scientific, and training resources, organized as a Pediatric Research Commons, which can be accessed by anyone with some parts of the Commons accessible only to our members. Across its 8 founding institutions, PEDSnet created a longitudinal data resource that dates back to 2009, cuts across all pediatric diseases, and includes all pediatric specialties.