Learning Session 12: Observational Studies’ Role in Learning Health Systems


Presenter: Amanda Dempsey, MD, MPH

Learning Objectives:

Participants will be able to:

  1. Understand key differences between OS and the “gold standard” of RCTs
  2. Understand when OS may provide valuable input to LHS in place or, or in addition to, RCT data
  3. Become familiar with some analytic methods pertinent to OS


  1. A Learning Health System Activity; Roundtable on Value and Science-Driven Health Care; Institute of Medicine. Observational Studies in a Learning Health System: Workshop Summary. Washington (DC): National Academies Press (US); 2013 Dec 2. 1, Introduction. Available from: https://www.ncbi.nlm.nih.gov/books/NBK201320/
  2. Stoto M, Oakes M, Stuart E, Savitz L, Priest EL, Zurovac J. Analytical Methods for a LearningHealth System: 1. Framing the Research Question. eGEMs (Generating Evidence & Methods to improve patient outcomes). 2017;5(1):28. DOI: http://doi.org/10.5334/egems.250. Available from: https://egems.academyhealth.org/article/10.5334/egems.250/