Prevention of Cerebrospinal Fluid Shunt Infections Using Antibiotic Impregnated Catheters

Project Summary: The goal of this study is to determine the efficacy of the use of antibiotic impregnated shunt tubing (with prophylactic intravenous antibiotic use) compared to prophylactic intravenous antibiotic use alone during CSF shunt surgery for the prevention of CSF shunt infection. We hypothesize that the use of antibiotic impregnated shunt tubing (with prophylactic intravenous antibiotic use) will demonstrate reduced odds of infection compared to surgeries with prophylactic intravenous antibiotic use alone.

Study Design. Retrospective observational cohort using data from the PEDSnet CDM.

Engagement. The Hydrocephalus Association (HA) has a strong history of engaging the hydrocephalus community in research efforts. Jenna Koschnitzky, PhD, the Director of Research Programs at HA, has been actively engaged in developing this full proposal, and throughout this study HA will engage patients through multiple avenues. HA will broadly engage the hydrocephalus community through periodic blog posts, and the study rationale along with the study progress will be posted on the HA website. Dr. Koschnitzky will be relied on to provide a patient’s/ parent’s perspective concerning all decisions made during the implementation and conduct of the study. She will also be involved in the drafting and review of any manuscripts that result from this study. 

Data Elements. Initial CSF shunt placements are defined as admissions with any International Classification of Diseases, Ninth Revision, Clinical Modification procedure code for extracranial ventricular shunt placement (02.3-02.35 except 02.39 alone), excluding those with any previous or concurrent procedure code for replacement (02.42) or removal of ventricular shunt (02.43), and/or any diagnosis code for shunt malfunction (996.2), and/or shunt infection (996.63). 

Collaborator Institutions