RECOVER: Researching COVID to Enhance Recovery

PCORnet Researchers Spearhead New Research Initiative Targeting Long-Haul COVID 


Investigators from two of the nation’s top health research institutions, Weill Cornell Medicine (WCM) and Children’s Hospital of Philadelphia (CHOP), are spearheading a new study aimed at understanding more about long-haul COVID-19. Dr. Christopher Forrest, professor of pediatrics and health care management at CHOP and principal investigator (PI) of the PEDSnet Clinical Research Network (CRN); and Dr. Rainu Kaushal, senior associate dean for clinical research and chair of the Department of Population Health Sciences at WCM and PI of the INSIGHT Clinical Research Network (CRN) were selected as two of the three leaders of the Electronic Health Record (EHR) Cohort Studies for the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative (  Drs. Forrest and Kaushal will lead the PCORnet-based EHR cohort alongside mPIs Dr. L. Charles Bailey (CHOP); Dr. Thomas Carton (Louisiana Public Health Institute); Dr. Grace Lee (Stanford Children’s Health); and Dr. Mark Weiner (WCM). The PCORnet Adult and Pediatric RECOVER EHR cohorts are enabled by the infrastructure of PCORnet®, the National Patient-Centered Clinical Research Network. 


The NIH RECOVER Initiative has awarded PCORnet researchers $20 million over one year to study the Post-Acute Sequelae of SARS-CoV-2 infection (PASC), often referred to as “long-haul COVID-19, in children and adults. This novel research opportunity leverages standardized and quality-assured clinical data, hundreds of scientists, streamlined processes, and clinical research infrastructure to rapidly generate evidence for PASC in both adult and pediatric populations. The EHR cohorts will contribute to the RECOVER Initiative in several meaningful ways, including the creation of new computable phenotypes and models that define PASC in children and adults. These computable patient characteristics can then be leveraged by clinical sites to identify and recruit eligible patients into studies which will help us gain valuable information about PASC. Finally, the EHR cohorts will help develop models and algorithms that predict risk of PASC while examining disparities between different populations and will further help to illustrate the effects of vaccines on PASC.  


The PCORnet-RECOVER EHR cohort is a collaboration between all eight PCORnet Clinical Research Networks (, representing 41 institutions across the United States. PCORnet provides an unprecedented breadth and depth of real-world data, nationally renowned investigators including informaticians, clinicians, and learning health system experts, and a robust track record for large-scale observational research, comparative effectiveness studies, surveys, and pragmatic clinical trials.  


Full Site List:

Albert Einstein College of Medicine

Children's National

Cincinnati Children's

Colorado Children's

Columbia University

Duke University/Health System



Intermountain Healthcare


Lurie Children's Hospital of Chicago

Medical College of Wisconsin

Medical University of South Carolina


Mount Sinai



Nicklaus Children's

Northwestern University

NYU Langone Health


Ochsner Health

Penn State College of Medicine

Seattle Children's


Temple University

The Children's Hospital of Philadelphia

The Ohio State University


UMC New Orleans (LSU)

Univeristy of Florida (OneFlorida)

Univeristy of Miami

University of Iowa

University of Michigan

University of Nebraska Medical Center

University of Pittsburgh

University of Utah


UT Southwestern

Vanderbilt University Medical Center

Wake Forest University Health Sciences

Weill Cornell Medicine



This project is active.