Tricyclic Antidepressants (TCA), Drug Exposure


Variable Name

rx_tca

Created

2026-03-31

Last Modified

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Abstract

This concept set is intended to identify patients exposed to TCAs, within a cohort of patients with chronic pain. The concept set is also intended to assist in the identification of patients who may have chronic pain.

Affiliation(s)

PEDSnet Data Coordinating Center
Seattle Children's Hospital

Funder(s)

Provenance

The concept set was created for the "Identifying Novel Signatures of Pediatric chronic pain in Real-world Environments" (INSPiRE) study.

Description

The code set was developed to identify drug exposures related to pain within a cohort of patients with primary chronic pain, and was also considered as part of the qualifying inclusion criteria to identify patients with chronic pain. TCAs include amitriptyline and nortriptyline.

Development Code

https://github.com/PEDSnet/palermo-inspire/blob/cp_drug_proc/cp_dev/code/driver_drug_codesets.R

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Identifying Novel Signatures of Pediatric chronic pain in Real-world Environments (INSPiRE)
Affiliation:Seattle Children's Hospital
One in four children experience chronic pain worldwide. Primary chronic pain is the most common type of chronic pain in childhood and is associated with negative impact on physical, psychological, and social functioning. Many children have mental health symptoms (e.g., anxiety, depression, insomnia) which impact on their pain experience and are associated with poor prognosis. Identification and treatment of pediatric chronic pain is unequal across groups distinguished by gender, race, ethnicity, language of care, insurance status, and disability status. To date, little is known about how chronic pain is identified and treated across the continuum of care (primary care to tertiary care) and how treatments can be prioritized to address complex mental health comorbidities.

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Creative Commons license

a CC-BY Attribution 4.0 License.
Except where otherwised noted, this item's license is described as a CC-BY Attribution 4.0 License.

Cite this Concept Set

Hirabayashi, K. (2026, March). Tricyclic Antidepressants (TCA), Drug Exposure. [Concept Set]. PEDSpace Knowledge Bank. https://doi.org/10.24373/pdsp-764