Retrospective analysis of Candida-related conditions in infancy and early childhood caries


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dc.contributor.authorJean J
dc.contributor.authorGoldberg S
dc.contributor.authorKhare R
dc.contributor.authorBailey LC
dc.contributor.authorForrest CB
dc.contributor.authorHajishengallis E
dc.contributor.authorKoo H
dc.contributor.otherUniversity of Pennsylvania
dc.contributor.otherDepartment of Biomedical and Health Informatics
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2026-02-17T17:53:17Z
dc.date.created2018-03-15
dc.date.issued2018-03-15
dc.description.abstract**Purpose:** <br>The purpose of this study was to assess whether there is an association between oral thrush or other Candida-related conditions in infancy and early childhood caries (ECC) diagnosed by pediatricians. **Methods:** <br>We conducted a retrospective cohort study using electronic health records from six national children's hospitals that participate in the PEDSnet research network. There were 1,012,668 children with a visit at ages one to 12 months and another visit at ages 13 to 71 months. The independent variables were diagnosis of thrush or Candida-related conditions in the first year of life, while the dependent variable was diagnosis of ECC between 13 to 71 months old. **Results:** <br>Oral thrush detection was strongly associated with ECC, particularly between 13 and 36 months (rate ratio between 2.7 [95 percent confidence interval (95% CI) equals 2.5 to 2.9; P<.001] and 3.0 [95% CI, equals 2.8 to 3.4; P<.001]). A similar trend was observed with other Candida-related conditions. **Conclusions:** <br>Oral thrush may be a risk factor for early childhood caries.
dc.identifier.citationJean J, Goldberg S, Khare R, Bailey LC, Forrest CB, Hajishengallis E, Koo H. Retrospective Analysis of Candida-related Conditions in Infancy and Early Childhood Caries. Pediatr Dent. 2018 Mar 15;40(2):131-135] <br>PMID: 29663914; PMCID: PMC5907929.
dc.identifier.urihttps://hdl.handle.net/20.500.14642/1535
dc.language.isoen-US
dc.publisherPediatric Dentistry
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/29663914/
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.subject.meshCandidiasis, Oral
dc.subject.meshDental Caries
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Factors
dc.titleRetrospective analysis of Candida-related conditions in infancy and early childhood caries
dspace.entity.typePublication

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