Impact of Early and Universal Hydroxyurea on Cerebrovascular Outcomes in Sickle Cell Disease

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dc.contributorAmerican Society of Hematology
dc.contributor.authorDain, Sarah
dc.contributor.authorBailey, Charles
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2024-07-09T19:50:28Z
dc.date.available2024-07-09T19:50:28Z
dc.descriptionThis study was intended to determine whether timely initiation of hydroxyurea (HU) prevents the development of early cerebrovascular changes in children with sickle cell disease (SCD). This project seeks to establish a link between early HU and cerebrovascular protection, promoting timely HU initiation, reducing the need for CRCT, and lowering stroke rates in children with SCD. #### Study Aims 1. Identify the impact of the 2014 NHLBI guidelines recommending early and universal HU on 1A) HU prescriptions and 1B) cerebrovascular outcomes in a national cohort of children and young adults born between 2009-2023. We hypothesize that the incidence of abnormal TCD and AIS has decreased since 2014, and that this occurred alongside an increase in HU prescriptions. 2. Determine the relationship between timely HU initiation before 2 years of age and the occurrence of cerebrovascular disease in children and young adults with SCD. We hypothesize that timely HU initiation by 2 years of age leads to a lower risk of abnormal TCD or AIS. #### Cohort Description Patients ages 0 to 21 years with homozygous sickle cell disease who initiate hematology care at a PEDSnet institution in the first year of life between 2009 and 2023. Patients with a history of malignancy or prematurity (less than 28 weeks) are excluded.
dc.description.abstractStudy to identify the impact of the 2014 NHBLI guidelines recommending early and universal hydroxyurea (HU) on HU prescriptions and cerebrovascular outcomes in a national cohort of children and young adults born between 2009-2023, and to determine the relationship between timely HU initiation before 2 years of age and the occurence of cerebrovascular disease in children and young adults with sickle cell disease.
dc.identifier.urihttps://pedsnet.org/metadata/handle/20.500.14642/715
dc.publisherPEDSnet
dc.relationDeep Vein Thrombosis
dc.relationBone Marrow Transplant
dc.relationOpioids
dc.relationFactor VIII
dc.relationMean Corpuscular Volume
dc.relationSplenic Sequestration
dc.relationProtein C
dc.relationProtein S
dc.relationObstructive Sleep Apnea
dc.relationSickle Cell Disease Associated Pain
dc.relationAcute Chest Syndrome
dc.relationFetal Hemoglobin
dc.relation"https://pedsnetapps.chop.edu/metadata/handle/20.500.14642/605"
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectStudy::Funded Study::PEDSnet Study
dc.subjectStudy::Query Development
dc.subject.meshHydroxyurea
dc.subject.meshUrea
dc.subject.meshAnemia, Sickle Cell
dc.subject.meshAnemia, Hemolytic, Congenital
dc.subject.meshHemoglobinopathies
dc.titleImpact of Early and Universal Hydroxyurea on Cerebrovascular Outcomes in Sickle Cell Disease
dspace.entity.typeStudy
local.admin.notehttps://chop365.sharepoint.com/:f:/r/teams/RSCH-ACRC/Shared%20Documents/PEDSnet/Front%20Door%20Requests/Dain_CHOP_Hydroxyurea?csf=1&web=1&e=LAsSHg
local.subject.flatPEDSnet Data Source
local.subject.flatFeasibility Query Investigation
project.startDate2024
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