Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents

Study Dates

2023

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PEDSnet

Abstract

Study to identify diagnosed symptoms, diagnosed health conditions, and medications associated with PASC in children.

Funder(s)

This research was made possible through the generous support of the Patient-Centered Outcomes Research Institute .

Provenance

Description

The study used electronic health records from nine US children’s hospitals for individuals younger than twenty-one years who underwent antigen or reverse transcriptase–polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 between March 1, 2020, and October 31, 2021, and had at least 1 encounter in the 3 years before testing.

In this large-scale, exploratory study, the burden of pediatric PASC that presented to health systems was low. Myocarditis was the most commonly diagnosed PASC-associated condition. Acute illness severity, young age, and comorbid complex chronic disease increased the risk of PASC.

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Related Study

The Researching COVID to Enhance Recovery (RECOVER) Post-Acute Sequelae of SARS-CoV-2 (PASC) Electronic Health Record (EHR) Cohort Study
Children's Hospital of Philadelphia; Janssen (United States)
Study to understand, prevent, and treat post-acute sequelae of SARS-CoV-2 (PASC), including Long COVID.

Related Publications

Rao S, Lee GM, Razzaghi H, et al. 2022. “Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents.” JAMA Pediatr. 176(10):1000-1009.
DOI: 10.1001/jamapediatrics.2022.2800

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Except where otherwised noted, this item's license is described as a CC-BY 4.0 Attribution license.