Understanding How Antibiotic Use Affects Childhood Obesity and Growth


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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorBlock, Jason
dc.contributor.authorForrest, Christopher
dc.contributor.otherHarvard Pilgrim Health Care
dc.date.accessioned2024-10-25T21:12:03Z
dc.descriptionAntibiotics are among the most valuable medical discoveries. Recent research on understanding of how bacteria in our gut use energy, however, raises concerns about whether broad-spectrum antibiotics, which are overprescribed for mild infections, prescribed in early infancy may cause obesity during childhood. Obesity is a very common and serious condition among US children, particularly children from disadvantaged populations. Yet those studies are too small and they lack diversity as well as modern scientific tools to gauge the extent to which prescribing antibiotics can lead to excess weight gain. PCORnet, the National Patient-Centered Clinical Research Network, comprising very large networks of data from electronic medical records, provides an ideal test bed to address this question. Further, it is not clear how caregivers and clinicians will use the results of earlier studies to decide which antibiotics to prescribe when faced with common infections like ear infections. #### Study Aims The objectives of the study are to assess the effects of different types, timing, and amount of antibiotic use in the first two years of life with (Specific Aim 1) body mass index (BMI) and obesity at ages 5 and 10 years and (Specific Aim 2) growth trajectories to age 5 years. In Specific Aim 3, we will address how big the effects of antibiotics on obesity are within subgroups of the population, such as different racial/ethnic groups and whether the child’s mother got antibiotics while she was pregnant.
dc.description.abstractStudy to assess the effects of different types, timing, and amount of antibiotic use in the first two years of life.
dc.identifier.urihttps://hdl.handle.net/20.500.14642/872
dc.publisherPEDSnet
dc.relation.isreferencedbyBlock JP, Bailey LC, Gillman MW, Lunsford D, et al. December 2018. "Early Antibiotic Exposure and Weight Outcomes in Young Children." *Pediatrics*. 142(6):e20180290. DOI: [10.1542/peds.2018-0290](doi.org/10.1542/peds.2018-0290) Erratum in: Pediatrics. 2019 Feb;143(2):e20183555.
dc.relation.isreferencedbyBlock JP, Bailey LC, Gillman MW, Lunsford D, Boone-Heinonen J, et al. July 2018. "PCORnet Antibiotics Childhood Growth Study Group. PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description." _Acad Pediatr_. 18(5):569-576. <br>DOI: [10.1016/j.acap.2018.02.008](doi.org/10.1016/j.acap.2018.02.008)
dc.relation.isreferencedbyBlock JP, Bailey LC, Gillman MW, Lunsford D, et al. December 2018. "PCORnet Antibiotics and Childhood Growth Study Group. Early Antibiotic Exposure and Weight Outcomes in Young Children. _Pediatrics_. 142(6):e20180290. <br>DOI: [10.1542/peds.2018-0290](doi.org/10.1542/peds.2018-0290)
dc.relation.isreferencedbyToh S, Rifas-Shiman SL, Lin PD, Bailey LC, Forrest CB, et al. May 2020. "PCORnet Antibiotics and Childhood Growth Study Group. Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study." _Pediatr Res_. 87(6):1086-1092. <br>DOI: [10.1038/s41390-019-0596-0](doi.org/10.1038/s41390-019-0596-0)
dc.relation.isreferencedbyBailey LC, Bryan M, Maltenfort M, Block JP, Teneralli R, Lunsford D, et al. April 2022. "PCORnet Antibiotics and Childhood Growth Study Group. Antibiotics prior to age 2 years have limited association with preschool growth trajectory." _Int J Obes (Lond)_. 46(4):843-850. <br>DOI: [10.1038/s41366-021-01023-w](doi.org/10.1038/s41366-021-01023-w)
dc.relation.isreferencedbyBailey, L.C., Bryan, M., Maltenfort, M. et al. 2022. "Antibiotics prior to age 2 years have limited association with preschool growth trajectory." _Int J Obes_. 46, 843–850 (2022). <br>DOI:[10.1038/s41366-021-01023-w](https://doi.org/10.1038/s41366-021-01023-w)
dc.relation.urihttps://github.com/PEDSnet/pcornet_abx_growth_study
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectRetrospective Study
dc.subjectCohort Study
dc.subjectObservational Study
dc.subjectClinical Study
dc.subjectADVANCE Data Source
dc.subjectGPC Data Source
dc.subjectINSIGHT Data Source
dc.subjectOneFlorida+ Data Source
dc.subjectPEDSnet Data Source
dc.subjectSTAR Data Source
dc.subjectPCORI-Funded Research
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshAnti-Infective Agents
dc.subject.meshGrowth Inhibitors
dc.subject.meshDrug-Related Side Effects and Adverse Reactions
dc.subject.meshGrowth Hormone
dc.subject.meshNutritional and Metabolic Diseases
dc.titleUnderstanding How Antibiotic Use Affects Childhood Obesity and Growth
dc.title.alternative2015.BLOJ.PCORI.DCC
dspace.entity.typeStudy
local.admin.note
local.admin.notehttps://atlassian.chop.edu/jira/browse/STUD-113
local.contributor.siteLeadPEDSnet Data Coordinating Center
local.contributor.sitesChildren�s Hospital of Philadelphia
local.contributor.sitesCincinnati Children�s Hospital Medical Center
local.contributor.sitesChildren�s Hospital Colorado
project.endDate2017
project.startDate2015
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relation.isPublicationOfStudy.latestForDiscoveryd19800d8-b102-4214-ae7b-c8fced1932fa

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