PEDSpace
Welcome to PEDSpace, a public data bank repository powered by PEDSnet. PEDSpace serves as a centralized hub where digital assets generated during PEDSnet studies are made readily accessible to researchers, clinicians, and stakeholders worldwide.
In PEDSpace, users can explore a wealth of resources to facilitate impactful research endeavors. Among these assets are meticulously defined variables, curated code sets, and modules for assessing data quality. Each component is designed to empower researchers with the tools necessary to navigate complex pediatric healthcare data effectively.
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Explore PEDSpace Collections
Browse a comprehensive set of functions to aid in data quality assessment of clinical datasets.
Browse a comprehensive index of PEDSnet projects, their associated publications, and related research materials.
Browse documentation, ETL specifications, and resources for participating PEDSnet sites.
Resources for use in defining cohorts and other analytic tasks for investigating EHR data.
Recent Submissions
- Early Antibiotic Exposure and Weight Outcomes in Young ChildrenCreated:2018-12Affiliation:Harvard Pilgrim Health Care Institute; Children's Hospital of Philadelphia; National Institutes of Health; North Fork School District; Kaiser Permanente Institute for Health Research; Nationwide Children's Hospital; Harvard Medical School; Vanderbilt University Medical Center; Pennington Biomedical Research Center; University Hospitals of Cleveland; New York University**Objectives:**
To determine the association of antibiotic use with weight outcomes in a large cohort of children. **Methods:**
Health care data were available from 2009 to 2016 for 35 institutions participating in the National Patient-Centered Clinical Research Network. Participant inclusion required same-day height and weight measurements at 0 to <12, 12 to <30, and 48 to <72 months of age. We assessed the association between any antibiotic use at <24 months of age with BMI z score and overweight or obesity prevalence at 48 to <72 months (5 years) of age, with secondary assessments of antibiotic spectrum and age-period exposures. We included children with and without complex chronic conditions. **Results:**
Among 1 792 849 children with a same-day height and weight measurement at <12 months of age, 362 550 were eligible for the cohort. One-half of children (52%) were boys, 27% were African American, 18% were Hispanic, and 58% received ≥1 antibiotic prescription at <24 months of age. At 5 years, the mean BMI z score was 0.40 (SD 1.19), and 28% of children had overweight or obesity. In adjusted models for children without a complex chronic condition at 5 years, we estimated a higher mean BMI z score by 0.04 (95% confidence interval [CI] 0.03 to 0.05) and higher odds of overweight or obesity (odds ratio 1.05; 95% CI 1.03 to 1.07) associated with obtaining any (versus no) antibiotics at <24 months. **Conclusions:**
Antibiotic use at <24 months of age was associated with a slightly higher body weight at 5 years of age. - Primary Hyperoxaluria Diagnosed After Kidney Transplant: A Review of the Literature and Case Report of Aggressive Renal Replacement Therapy and Lumasiran to Prevent Allograft LossCreated:2021-12Affiliation:Cincinnati Children's Hospital Medical Center; University of Cincinnati College of MedicinePrimary hyperoxaluria type 1 is a rare inherited disorder caused by abnormal liver glyoxalate metabolism leading to overproduction of oxalate, progressive kidney disease, and systemic oxalosis. While the disorder typically presents with nephrocalcinosis, recurrent nephrolithiasis, and/or early chronic kidney disease, the diagnosis is occasionally missed until it recurs after kidney transplant. Allograft outcomes in these cases are typically very poor, often with early graft loss. Here we present the case of a child diagnosed with primary hyperoxaluria type 1 after kidney transplant who was able to maintain kidney function, thanks to aggressive renal replacement therapy as well as initiation of a new targeted therapy for this disease. This case highlights the importance of having a high index of suspicion for primary hyperoxaluria in patients with chronic kidney disease and nephrocalcinosis/nephrolithiasis or with end stage kidney disease of uncertain etiology, as initiating therapies early on may prevent poor outcomes.
- Understanding the Bariatric Patient Perspective in the National Patient-Centered Clinical Research Network (PCORnet) Bariatric StudyCreated:2020-05Affiliation:Kaiser Permanente Southern California,; Vanderbilt University; Smart Patients, Inc.; Louisianna Public Health Institute; University of Alabama at Birmingham; Philadelphia College of Osteopathic Medicine,; Obesity Action Coalition; Massachusetts General Hospital; Global Healthy Living Foundation; Cincinnati Children's Hospital Medical Center; Facebook, Inc.; Kaiser Permanente Washington Health Research Institute; Community Partners Network; University of Pittsburgh Medical Center**Background:**
In 2016, the Patient-Centered Outcomes Research Institute funded the National Patient Centered Clinical Research Network (PCORnet) Bariatric Study (PBS). Understanding the experience of postoperative patients was a key component of this study. **Methods:**
Nine focus groups were conducted in Southern California, Louisiana, Pennsylvania, and Ohio and in a national advocacy conference for patients with obesity. Participants were identified and recruited in both clinical and community settings. Focus group transcripts were analyzed using an iterative inductive-deductive approach to identify global overarching themes. **Results:**
There were 76 focus group participants. Participants were mostly women (81.4%), had primarily undergone gastric sleeve (47.0%), were non-Hispanic white (51.4%), had some college education (44.3%), and made $100,000 annual income or less (65.7%). Qualitative findings included negative reactions patients received from friends, family, and co-workers once they disclosed that they had bariatric surgery to lose weight; and barriers to follow-up care included insurance coverage, emotional and situational challenges, and physical pain limiting mobility. **Conclusions:**
These findings confirm the other qualitative findings in this area. The approach to bariatric surgery should be expanded to provide long-term comprehensive care that includes in-depth postoperative lifetime monitoring of emotional and physical health. - Is Local Air Pollution Concentration a Moderator or Mediator of the Association Between Residential Greenspace and Pediatric Asthma Exacerbations? A Longitudinal Study of Pediatric Patients in Philadelphia, PennsylvaniaCreated:2025-05Affiliation:Ichan School of Medicine at Mount Sinai; Drexel University; Children's Hospital of Philadelphia**Background:**
Despite mixed evidence supporting the link between greenspace and asthma exacerbations, several studies suggest a negative association. The mechanisms underlying this relationship are unclear, with air pollution concentrations potentially playing a key role. This study investigated whether air pollution concentrations modify or mediate the relationship between residential greenspace and pediatric asthma exacerbations. **Methods:**
Data were drawn from a pediatric asthma cohort at Children's Hospital of Philadelphia (2011-2016), including children aged <18 years. Participants were followed from their initial visit until their first asthma exacerbation. Greenspace (tree canopy, grass/shrub cover) near homes was assessed. Daily air pollution data, including PM2.5, ozone, NO2, and SO2, were obtained from the US Environmental Protection Agency. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated, adjusting for individual and neighborhood characteristics. Effect modification by air pollution concentrations was tested, and causal mediation analyses were conducted. **Results:**
On days with high SO2 concentrations, children living near the highest quartile of tree canopy coverage had a 14% lower incidence of asthma exacerbations compared to those in the lowest quartile (HR = 0.86, 95% CI = 0.74, 0.98). Conversely, on days with low SO2 concentrations, tree canopy coverage was associated with a nonsignificant 12% higher incidence (HR = 1.12, 95% CI = 0.97, 1.28). Similar patterns were observed for NO2, but no interactions were found for PM2.5 or ozone. Mediation analyses indicated no significant mediation by air pollution. **Conclusion:**
In urban areas with high SO2 or NO2 levels, greenspace near homes may support children with asthma by mitigating air pollution's impact, suggesting greenspace-based urban strategies. - Racial/Ethnic Disparities in Healthcare Worker Experiences During the COVID-19 Pandemic: An Analysis of the HERO RegistryCreated:2022-03-05Affiliation:Duke Clinical Research Institute; Children's Hospital of Philadelphi; Johns Hopkins University; Vanderbilt University Medical Center; Duke University**Background:**
The extent to which healthcare worker (HCWs) experiences during the COVID-19 pandemic vary by race or ethnicity after adjustment for confounding factors is not currently known. **Methods:**
We performed an observational prospective cohort study of 24,769 healthcare workers from 50 U.S. states and the District of Columbia, enrolled between April 10, 2020 and June 30, 2021, and evaluated participant experiences during the COVID-19 pandemic, including testing, diagnosis with COVID-19, emotional experiences, burnout, and interest in vaccines and vaccine clinical trials. **Findings:**
After adjustment for professional role, medical history, and community characteristics, Black and Asian participants were less likely to receive SARS-CoV-2 viral testing (adjusted odds ratio (aOR) 0·82 [0·70, 0·96], p=0·012 and aOR 0·77 [0·67, 0·89], p<0·001 respectively) than White participants. Hispanic participants were more likely to have evidence of COVID-19 infection (aOR 1·23 (1·00, 1·50, p=0·048). Black and Asian participants were less likely to report interest in a COVID-19 vaccine (aOR 0·11 [0·05, 0·25], p<0·001 and aOR 0·48 [0·27, 0·85] p=0·012). Black participants were less likely to report interest in participating in a COVID-19 vaccine trial (aOR = 0·39 [0·28, 0·54], p<0·001). Black participants were also less likely to report 3 or more daily emotional impacts of COVID-19 (aOR = 0·66 [0·53, 0·82], p=<0·001). Black participants were additionally less likely to report burnout (aOR = 0·66 ([0·49, 0·95], p=0·025). **Interpretation:**
In a large, national study of healthcare workers, after adjustment for individual and community characteristics, race/ethnicity disparities in COVID-19 outcomes persist. Future work is urgently needed to understand precise mechanisms behind these disparities and to develop and implement targeted interventions to improve health equity for healthcare workers. **Funding:**
This work was funded by the Patient-Centered Outcomes Research Institute (PCORI), Contract # COVID-19-2020-001.