This collection consists of phenotypic cohort definitions for patients with diseases affecting the skin, hair, nails, and connective tissues and include inflammatory, autoimmune, infectious, and genetic conditions. Phenotype logic may incorporate dermatologic diagnosis codes, biopsy results, imaging of soft tissues, use of immunosuppressants or topical therapies, and dermatology encounters. Example phenotypes include “Atopic Dermatitis,” identified by diagnosis codes and topical corticosteroid use, and “Systemic Sclerosis,” which may require diagnosis confirmation, clinical features like skin thickening, and lab results (e.g., ANA positivity).