Study Domain
PRESERVE: Preserving Kidney Function in Children with Chronic Kidney Disease
Permanent URI for this domainhttps://pedsnet.org/metadata/handle/20.500.14642/735
Preserving Kidney Function in Children with Chronic Kidney Disease or PRESERVE was a multi-year PCORI-funded project to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD).
Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation.
Specific aims of the study included enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients’ lived experiences related to blood pressure management.
Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation.
Specific aims of the study included enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients’ lived experiences related to blood pressure management.