Paxlovid, Drug Exposure


Variable Name

rx_paxlovid

Created

2022-10-10

Last Modified

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Files

2 Downloads↓
rx_2022_10_Paxlovid_V1.csv (6.96 KB)
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FIND_PAXLOVID_FUNCTION.R (4.69 KB)
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Tags

Level of Review

Data Model

Abstract

The concept set was intended to identify all patients with a drug_exposure record indicating a Paxlovid exposure (nirmatrelvir/ritonavir).

Affiliation(s)

PEDSnet Data Coordinating Center

Funder(s)

Provenance

This concept set was originally developed to extract COVID patients out of the PEDSnet CDM observation table for the the Researching COVID to Enhance Recovery (RECOVER) Post-Acute Sequelae of SARS-CoV-2 (PASC) Electronic Health Record (EHR) Cohort Study. RECOVER was a was a long-term NIH-funded project focused on analyzing the COVID-19 outbreak, especially the long term health impacts of the pandemic. Thid codeset has also been used in a RECOVER Y1, Q3 query and used to define a cohort in the "COVID and Diabetes Assessment Study (CODA)". These concepts were later reviewed and refined for a brief report on pediatric nirmatrelvir and ritonavir prescribing patterns, "Pediatric Nirmatrelvir/Ritonavir Prescribing Patterns During the COVID-19 Pandemic" (Bose-Brill et. al., 2022).

Description

One of several codesets in the PEDSnet observation_derivation_recover(ODR) workflow to extract COVID-19 patients from the PEDSnet CDM observation table. This concept set was used to identify pediatric patients under 18 who were prescribed Paxlovid.

The concept set was developed by identifying RxNorm codes at the SCDF/SCDG level and descendants indicating Paxlovid, then string searching for the terms ‘paxlovid’, ‘ritonavir’, and ‘nirmatrelvir’ in ‘concept_name’. Codes were identified in the ‘code_type’ column as ‘Paxlovid’ (indicating nirmatrelvir/ritonavir), ‘nirmatrelvir’ (indicating nirmatrelvir alone) and ‘ritonavir’ (indicating ritonavir alone).

Please note, this concept set should not be used without appropriate accompanying logic to identify Paxlovid; the concept set contains individual ingredients that comprise the combination. Ritonavir and nirmatrelvir exposure must occur together on the same date to indicate a combination drug prescription. The attached file, FIND_PAXLOVID_FUNCITON.R, provides logic showing how the concept set can be used.

Development Code

https://atlassian.chop.edu/bitbucket/projects/COV/repos/paxlovid_brief/browse

Vocabulary

Medication Classification Level



Clinical Subjects Headings

Preview Concept Set

rx_2022_10_Paxlovid_V1.csv (51 rows)

Interactive spreadsheet view available in browser

Data Source

Related Phenotype

Related Person

Related Study

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The Researching COVID to Enhance Recovery (RECOVER) Post-Acute Sequelae of SARS-CoV-2 (PASC) Electronic Health Record (EHR) Cohort Study
Affiliation:Children's Hospital of Philadelphia
Study to understand, prevent, and treat post-acute sequelae of SARS-CoV-2 (PASC), including Long COVID.
#### [View the RECOVER initiative website here.](https://recovercovid.org/)
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The COvid and Diabetes Assessment (CODA) Study
Affiliation:Vanderbilt University Medical Center
Study to rapidly identify, recruit, and retain diverse cohorts of English and Spanish speaking pediatric and adult patients with recently diagnosed type one or type two diabetes (T1D or T2D) to examine the relationship between SARS-CoV-2 and COVID-19 infection and diabetes.

Related Concept Set

Related Code

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Observation Derivation RECOVER
Created:2022Affiliation:PEDSnet Data Coordinating Center
Code to pull PASC/COVID-relevant observations from the CDM and metadata to describe the resulting tables.

Related Publications

Bose-Brill S, Hirabayashi K, Pajor NM, Rao S, Mejias A, Jhaveri R, Forrest CB, et al. 2022. “Pediatric Nirmatrelvir/Ritonavir Prescribing Patterns During the COVID-19 Pandemic”. medRxiv [Preprint]. 2022 Dec 26:2022.12.23.22283868.
DOI: 10.1101/2022.12.23.22283868
Update in: Hosp Pediatr. 2024 Aug 1;14(8):e341-e348.

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Creative Commons license

a CC-BY Attribution 4.0 License.
Except where otherwised noted, this item's license is described as a CC-BY Attribution 4.0 License.

Cite this Concept Set

Hirabayashi, K. (2022, October). Paxlovid, Drug Exposure. [Concept Set]. PEDSpace Knowledge Bank. https://doi.org/10.24373/pdsp-320