ConceptSet

Graves Disease, Diagnosed


Variable Name

dx_graves

Refreshed Date

2021-11

Last Modified

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dx_2021_11_GravesDisease_V1.csv (1.92 KB)
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This concept set is inteded to identify patients with a diagnosis of Graves’ Disease.

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Provenance

This was developed as part of autoimmune/chronic conditions for a RECOVER study manuscript exploring features of children with PASC.

Description

This concept set contains condition codes for and related to Graves’ disease. The code list was generated by searching for all descendants of the SNOMED code 353295004 (Graves’ disease) plus all ICD10 or ICD10CM codes mapping to those SNOMED descendants. String matching was also performed looking for the string “graves” in the condition domain and excluding the terms “family history”, “forte”, “migravess”. The concept set was limited to ICD10, ICD10CM, and SNOMED vocabularies.

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dx_2021_11_GravesDisease_V1.csv (26 rows)

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Published Research Applications

Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents
Published:2022-08-22Journal:JAMA Pediatrics
**Importance**
The postacute sequelae of SARS-CoV-2 infection (PASC) has emerged as a long-term complication in adults, but current understanding of the clinical presentation of PASC in children is limited. **Objective**
To identify diagnosed symptoms, diagnosed health conditions, and medications associated with PASC in children. **Design, setting and participants**
This retrospective cohort study used electronic health records from 9 US children's hospitals for individuals younger than 21 years who underwent antigen or reverse transcriptase-polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 between March 1, 2020, and October 31, 2021, and had at least 1 encounter in the 3 years before testing. **Exposures**
SARS-CoV-2 positivity by viral test (antigen or RT-PCR). **Main outcomes and measures**
Syndromic (symptoms), systemic (conditions), and medication PASC features were identified in the 28 to 179 days following the initial test date. Adjusted hazard ratios (aHRs) were obtained for 151 clinically predicted PASC features by contrasting viral test-positive groups with viral test-negative groups using proportional hazards models, adjusting for site, age, sex, testing location, race and ethnicity, and time period of cohort entrance. The incidence proportion for any syndromic, systemic, or medication PASC feature was estimated in the 2 groups to obtain a burden of PASC estimate. **Results**
Among 659 286 children in the study sample, 348 091 (52.8%) were male, and the mean (SD) age was 8.1 (5.7) years. A total of 59 893 (9.1%) tested positive by viral test for SARS-CoV-2, and 599 393 (90.9%) tested negative. Most were tested in outpatient testing facility settings (322 813 [50.3%]) or office settings (162 138 [24.6%]). The most common syndromic, systemic, and medication features were loss of taste or smell (aHR, 1.96; 95% CI, 1.16-3.32), myocarditis (aHR, 3.10; 95% CI, 1.94-4.96), and cough and cold preparations (aHR, 1.52; 95% CI, 1.18-1.96), respectively. The incidence of at least 1 systemic, syndromic, or medication feature of PASC was 41.9% (95% CI, 41.4-42.4) among viral test-positive children vs 38.2% (95% CI, 38.1-38.4) among viral test-negative children, with an incidence proportion difference of 3.7% (95% CI, 3.2-4.2). A higher strength of association for PASC was identified in those cared for in the intensive care unit during the acute illness phase, children younger than 5 years, and individuals with complex chronic conditions. **Conclusions and relevance**
In this large-scale, exploratory study, the burden of pediatric PASC that presented to health systems was low. Myocarditis was the most commonly diagnosed PASC-associated condition. Acute illness severity, young age, and comorbid complex chronic disease increased the risk of PASC.

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a CC-BY Attribution 4.0 License.
Except where otherwised noted, this item's license is described as a CC-BY Attribution 4.0 License.


Version History

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VersionDateSummary
2
 2026-08-14 15:26:36
Study-specific codeset for a DCCWW study.
1*
 2024-06-10 15:03:19
* Selected version