End-Stage Kidney Disease (ESKD)
dc.contributor.author | Nguyen, Nhat |
dc.contributor.author | Hirabayashi, Katie |
dc.contributor.other | Children's Hospital of Philadelphia |
dc.contributor.other | PEDSnet Data Coordinating Center |
dc.date.accessioned | 2025-03-14T15:01:35Z |
dc.date.created | 2025-03 |
dc.description | The computable phenotype was developed to query patients ESKD patients (patients who had either undergone kidney chronic dialysis or kidney transplant) and was validated against a <a href="https://usrds-adr.niddk.nih.gov/2024/chronic-kidney-disease/ckd-analytical-methods">USRDS dataset</a> and a subset of chart review patients. The most optimal computable phenotype for identifying ESKD required one code from Group A (more specific) or two distinct codes from Group B (more sensitive) and at least five eGFR measurements ≤15 mL/min/1.73m² on different days. This algorithm achieved: - **F1 Score:** 0.92 (95% CI 0.88-0.95) - **Sensitivity:** 94.6% (95% CI 92.8%-96.2%) - **PPV:** 86.8.7% (95% CI 84.4%-89.3%). #### Related Concept Sets - https://usrds-adr.niddk.nih.gov/2024/chronic-kidney-disease/ckd-analytical-methods - https://github.com/PRESERVE-Coordinating-Center/PRESERVE_Variables/blob/main/codesets/condition/ckd_dx_usrds.csv |
dc.description.abstract | A phenotype to identify patients with end-stage kidney disease (ESKD), defined as having either chronic dialysis or kidney transplant based on a combination of kidney transplant, kidney biopsy, and kidney dialysis procedure and condition codes, and eGFR values. |
dc.identifier.uri | https://pedsnet.org/metadata/handle/20.500.14642/982 |
dc.provenance | Developed as part of the Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) study. |
dc.publisher | PEDSnet |
dc.relation | Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) |
dc.relation.uri | https://github.com/PRESERVE-Coordinating-Center/PRESERVE_Variables/blob/main/analytic_code/eskd_cp_phenotype.R |
dc.rights | a CC-BY Attribution 4.0 license. |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ |
dc.subject | Computable Phenotyping::Content Data Model::PCORnet Data Model |
dc.subject | Computable Phenotyping::Phenotype Evaluation::Validated |
dc.subject | Computable Phenotyping::Phenotype Development Strategy::Rules-Based (Structured Data-Only) |
dc.subject.mesh | Kidney Failure, Chronic |
dc.subject.mesh | Renal Insufficiency, Chronic |
dc.subject.mesh | Renal Insufficiency |
dc.subject.mesh | Chronic Kidney Diseases of Uncertain Etiology |
dc.subject.mesh | Kidney Diseases |
dc.subject.mesh | Urogenital Diseases |
dc.subject.other | ICD-10-PCS |
dc.subject.other | SNOMED |
dc.subject.other | ICD-9-Proc |
dc.subject.other | CPT |
dc.subject.other | HCPCS |
dc.subject.other | ICD-9-CM |
dc.subject.other | ICD-10-CM |
dc.subject.other | ICD-10-GM |
dc.subject.other | CIM10 |
dc.subject.other | KCD7 |
dc.title | End-Stage Kidney Disease (ESKD) |
dspace.entity.type | Phenotype |
local.quality.status | Research-Ready |
local.subject.flat | PCORnet Data Model |
local.subject.flat | Validated |
local.subject.flat | Rules-Based (Structured Data-Only) |
local.subject.flat | Any Age Patient Population |
local.subject.flat | Any Gender Identity Patient Population |
local.subject.flat | Any Race/Ethnicity Patient Population |
relation.isStudyOfPhenotype | 6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae |
relation.isStudyOfPhenotype.latestForDiscovery | 6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae |
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