End-Stage Kidney Disease (ESKD)
| dc.contributor.author | Nguyen, Nhat |
| dc.contributor.author | Hirabayashi, Katie |
| dc.contributor.other | Children's Hospital of Philadelphia |
| dc.contributor.other | PEDSnet Data Coordinating Center |
| dc.date.accessioned | 2025-03-14T15:01:35Z |
| dc.date.created | 2025-03 |
| dc.description | The computable phenotype was developed to query patients ESKD patients (patients who had either undergone kidney chronic dialysis or kidney transplant) and was validated against a <a href="https://usrds-adr.niddk.nih.gov/2024/chronic-kidney-disease/ckd-analytical-methods">USRDS dataset</a> and a subset of chart review patients. The most optimal computable phenotype for identifying ESKD required one code from Group A (more specific) or two distinct codes from Group B (more sensitive) and at least five eGFR measurements ≤15 mL/min/1.73m² on different days. This algorithm achieved: - **F1 Score:** 0.92 (95% CI 0.88-0.95) - **Sensitivity:** 94.6% (95% CI 92.8%-96.2%) - **PPV:** 86.8.7% (95% CI 84.4%-89.3%). #### Related Concept Sets - https://usrds-adr.niddk.nih.gov/2024/chronic-kidney-disease/ckd-analytical-methods - https://github.com/PRESERVE-Coordinating-Center/PRESERVE_Variables/blob/main/codesets/condition/ckd_dx_usrds.csv |
| dc.description.abstract | A phenotype to identify patients with end-stage kidney disease (ESKD), defined as having either chronic dialysis or kidney transplant based on a combination of kidney transplant, kidney biopsy, and kidney dialysis procedure and condition codes, and eGFR values. |
| dc.identifier.uri | https://hdl.handle.net/20.500.14642/982 |
| dc.identifier.uri | https://doi.org/10.24373/pdsp-4 |
| dc.provenance | Developed as part of the Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) study. |
| dc.publisher | PEDSnet |
| dc.relation.uri | https://github.com/PRESERVE-Coordinating-Center/PRESERVE_Variables/blob/main/analytic_code/eskd_cp_phenotype.R |
| dc.rights | a CC-BY Attribution 4.0 license. |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ |
| dc.subject | Rules-Based (Structured Data-Only) |
| dc.subject.mesh | Kidney Failure, Chronic |
| dc.subject.mesh | Renal Insufficiency, Chronic |
| dc.subject.mesh | Renal Insufficiency |
| dc.subject.mesh | Chronic Kidney Diseases of Uncertain Etiology |
| dc.subject.mesh | Kidney Diseases |
| dc.subject.mesh | Urogenital Diseases |
| dc.subject.other | ICD-10-PCS |
| dc.subject.other | SNOMED |
| dc.subject.other | ICD-9-Proc |
| dc.subject.other | CPT |
| dc.subject.other | HCPCS |
| dc.subject.other | ICD-9-CM |
| dc.subject.other | ICD-10-CM |
| dc.subject.other | ICD-10-GM |
| dc.subject.other | CIM10 |
| dc.subject.other | KCD7 |
| dc.title | End-Stage Kidney Disease (ESKD) |
| dspace.entity.type | Phenotype |
| local.quality.status | Research-Ready |
| local.subject.DataModel | PCORnet Data Model |
| local.subject.DevPop | Any Age Patient Population |
| local.subject.DevPop | Any Gender Patient Population |
| local.subject.DevPop | Any Race/Ethnicity Patient Population |
| local.subject.validation | External Standard |
| local.variable.name | dx_eskd |
| relation.isStudyOfPhenotype | 6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae |
| relation.isStudyOfPhenotype.latestForDiscovery | 6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae |
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