Neighborhood Greenspace as a Protective Factor Against Childhood Asthma
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Abstract
Emerging evidence suggests that exposure to vegetated land cover, or ‘greenspace’, particularly in early life, may prevent development of asthma. This study aims to investigate neighborhood greenspace in relation to the asthma incidence, in a longitudinal cohort of over 170,000 children living in the Philadelphia metropolitan region, followed from infancy.
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This study provides a robust analysis of the potential for urban greenspace exposure in early life to protect against development of asthma. In addition, information from subgroup and phenotype analyses provides clues regarding the mechanisms by which greenspace may affect risk of asthma, as well as the scope of potential impact.
Study Aims
- Investigate the association between neighborhood greenspace and asthma incidence from infancy through childhood (specifically, ages 2, 7 and 12) in a cohort of urban and suburban children.
- Evaluate modification of the relationship between greenspace and asthma incidence by other neighborhood characteristics that may alter risk or vulnerability, including air pollution (PM2.5, O3), traffic, urban status, and sociodemographics.
- Describe heterogeneity of the association with neighborhood greenspace among asthma phenotypes.
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Yen YT, Schinasi LH, Sánchez BN, Melly S, Moore K, Forrest CB, Kenyon CC, Kondo MC, De Roos AJ. 2025 May. “Is local air pollution concentration a moderator or mediator of the association between residential greenspace and pediatric asthma exacerbations? A longitudinal study of pediatric patients in Philadelphia, Pennsylvania.” Int J Hyg Environ Health. 266:114546. Epub 2025 Mar 6. PMID: 40054040.
DOI: 10.1016/j.ijheh.2025.114546
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