Neighborhood Greenspace as a Protective Factor Against Childhood Asthma

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dc.contributorNational Institutes of Health
dc.contributor.authorDeRoos, Anneclaire
dc.contributor.authorKenyon, Chen
dc.contributor.otherDrexel University
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2025-01-09T21:06:10Z
dc.descriptionThis study provides a robust analysis of the potential for urban greenspace exposure in early life to protect against development of asthma. In addition, information from subgroup and phenotype analyses provides clues regarding the mechanisms by which greenspace may affect risk of asthma, as well as the scope of potential impact. #### Study Aims 1. Investigate the association between neighborhood greenspace and asthma incidence from infancy through childhood (specifically, ages 2, 7 and 12) in a cohort of urban and suburban children. 2. Evaluate modification of the relationship between greenspace and asthma incidence by other neighborhood characteristics that may alter risk or vulnerability, including air pollution (PM2.5, O3), traffic, urban status, and sociodemographics. 3. Describe heterogeneity of the association with neighborhood greenspace among asthma phenotypes.
dc.description.abstractEmerging evidence suggests that exposure to vegetated land cover, or ‘greenspace’, particularly in early life, may prevent development of asthma. This study aims to investigate neighborhood greenspace in relation to the asthma incidence, in a longitudinal cohort of over 170,000 children living in the Philadelphia metropolitan region, followed from infancy.
dc.identifier.urihttps://hdl.handle.net/20.500.14642/938
dc.publisherPEDSnet
dc.relationAsthma, SNOMED-only
dc.relationAnti-Asthmatic Agent, Drug Exposure
dc.relationAnti-Asthmatic Agent, Drug Exposure
dc.relationAcute Lower Respiratory Infection (Non-Asthma)
dc.relationAllergies, Food
dc.relationAllergies, Non-Food, Drug, or Respiratory
dc.relationAllergic Otitis Media
dc.relationAcute Lower Respiratory Infection
dc.relationDermatitis, Contact
dc.relationEosinophilic Esophagitis
dc.relationAcute Upper Respiratory Infection
dc.relationAnaphylactic Shock
dc.relationAllergic Conjunctivitis
dc.relationEosinophilia
dc.relationAllergic Contact Dermatitis
dc.relationWheeze
dc.relationUrticaria
dc.relationAllergies, Drug
dc.relationPulmonary Eosinophilia
dc.relationChronic Sinusitis
dc.relationAllergies, Respiratory
dc.relationAllergic Gastritis and Colitis
dc.relationLactose Intolerance
dc.relation.isreferencedbyYen YT, Schinasi LH, Sánchez BN, Melly S, Moore K, Forrest CB, Kenyon CC, Kondo MC, De Roos AJ. 2025 May. "Is local air pollution concentration a moderator or mediator of the association between residential greenspace and pediatric asthma exacerbations? A longitudinal study of pediatric patients in Philadelphia, Pennsylvania." _Int J Hyg Environ Health_. 266:114546. Epub 2025 Mar 6. PMID: 40054040. <br>DOI: [10.1016/j.ijheh.2025.114546](https://doi.org/10.1016/j.ijheh.2025.114546)
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectPEDSnet Data Source
dc.subjectInvestigator-Led Study
dc.subjectCohort Study
dc.subjectLongitudinal Study
dc.subjectFederally Funded Research
dc.subject.meshAsthma
dc.subject.meshBronchial Diseases
dc.subject.meshLung Diseases, Obstructive
dc.subject.meshEnvironmental Pollution
dc.subject.meshPublic Health
dc.subject.meshAir Pollution
dc.subject.meshEnvironmental Exposure
dc.subject.meshHome Environment
dc.titleNeighborhood Greenspace as a Protective Factor Against Childhood Asthma
dspace.entity.typeStudy
local.admin.noteThe PM for this project is Ellen McQuaid. The PEDSnet effort for this ended in May of last year. The study had an NCE to 1/31/25 which the other CHOP study team members (not within PEDSnet) continued the work on.
local.subject.flatPEDSnet Data Source
local.subject.flatInvestigator-Led Study
local.subject.flatCohort Study
local.subject.flatLongitudinal Study
local.subject.flatFederally Funded Research
project.endDate2023-08
project.startDate2022-09
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