Rationale, Design and Methods of the Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) Study

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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorDenburg, Michelle
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2025-01-13T14:38:51Z
dc.descriptionHypertension is a major modifiable contributor to loss of kidney function in chronic kidney disease (CKD). The purpose of PRESERVE is to provide evidence to inform shared decision-making regarding blood pressure management for children with CKD. PRESERVE is a consortium of 16 health care institutions in PCORnet, the National Patient-Centered Clinical Research Network, and includes electronic health record data for >19,000 children with CKD. PRESERVE will (1) expand the PCORnet infrastructure for research in pediatric CKD by adding kidney-specific variables and linking electronic health record data to other kidney disease databases; (2) compare the effectiveness of alternative strategies for monitoring and treating hypertension on preserving kidney function; and (3) assess the lived experiences of patients and caregivers related to blood pressure management. #### Study Design Multicenter retrospective cohort study (clinical outcomes) and cross-sectional study (patient-reported outcomes [PROs]). #### Cohort Description PRESERVE included approximately 20,000 children between January 2009-December 2022 with mild-moderate CKD from 15 health care institutions that participate in 6 PCORnet Clinical Research Networks (PEDSnet, STAR, GPC, PaTH, CAPRiCORN, and OneFlorida+). <br>Inclusion Criteria: - ≥ 1 nephrologist visit - ≥ 2 estimated glomerular filtration rate (eGFR) values in the range of 30 to < 90 mL/min/1.73 m2 separated by ≥ 90 days without an intervening value ≥ 90 mL/min/1.73 m2 and no prior dialysis or kidney transplant.
dc.description.abstractStudy to provide new knowledge to inform shared decision-making regarding blood pressure (BP) management for pediatric chronic kidney disease (CKD). PRESERVE will compare the effectiveness of alternative strategies for monitoring and treating hypertension on preserving kidney function; expand the National Patient-Centered Clinical Research Network (PCORnet) common data model by adding pediatric- and kidney-specific variables and linking electronic health record data to other kidney disease databases; and assess the lived experiences of patients related to BP management.
dc.identifier.urihttps://pedsnet.org/metadata/handle/20.500.14642/946
dc.publisherPEDSnet
dc.relation.isreferencedbyDenburg MR, Razzaghi H, Goodwin Davies AJ, Dharnidharka V, et al. September 2023. "The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods." _Kidney Medicine_. ;5(11):100722. <br>DOI: [10.1016/j.xkme.2023.100722](https://doi.org/10.1016/j.xkme.2023.100722)
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectStudy::Cohort Study::Retrospective Study
dc.subjectStudy::Cross-Sectional Study
dc.subjectStudy::Funded Study::PEDSnet Study
dc.subjectStudy::Funded Study::PCORnet Study
dc.subject.meshBlood Pressure
dc.subject.meshHypertension
dc.subject.meshVascular Diseases
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshRenal Insufficiency
dc.subject.meshKidney Diseases
dc.titleRationale, Design and Methods of the Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) Study
dspace.entity.typeStudy
local.subject.flatRetrospective Study
local.subject.flatCross-Sectional Study
local.subject.flatPEDSnet Data Source
local.subject.flatPCORI Funded Research
local.subject.flatCohort Study
project.startDate2023-09
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relation.isOrgUnitOfStudy.latestForDiscoveryda841c56-bb55-405c-8b50-8f221ef62890
relation.isStudyOfStudy6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae
relation.isStudyOfStudy.latestForDiscovery6df51ca1-7a01-4551-b1f1-ca70aaf2c5ae

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PRESERVE: Preserving Kidney Function in Children with Chronic Kidney Disease