Derivation of Pediatric Blood Pressure References from Electronic Health Records

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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorMitsnefes, Mark
dc.contributor.authorDenburg, Michelle
dc.contributor.otherCincinnati Children's Hospital Medical Center
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2025-01-13T14:38:49Z
dc.descriptionStudy of a sample of 292,412 children (1,085,083 BP measurements), ages 3-17 years (53% female), with no chronic medical conditions, who were not overweight/obese and who were primarily seen for general paediatric care in outpatient settings. Approximately 45,000-75,000 children contributed data to each age category. The PEDSnet systolic BP percentile values were 1-4 mmHg higher than AAP CPG BP values across age-sex-height groups, with larger differences observed in younger children. Diastolic BP values were also higher in younger children; starting with age 7 years, diastolic BP percentile values were 1-3 mmHg lower than AAP CPG values. Cohen's Kappa was 0.90 for systolic BP, 0.66 for diastolic BP, and 0.80 overall indicating excellent agreement between PEDSnet and 2017 AAP CPG data for systolic BP and substantial agreement for diastolic BP. #### Study Design Using data collected 01/01/2009-8/31/2021 from eight large children's healthcare organisations in PEDSnet, we applied a mixed-effects polynomial regression model with random slopes to generate Z-scores and BP percentiles and compared them with currently used normative BP distributions published in the 2017 American Academy of Paediatrics (AAP) Clinical Practise Guidelines (CPG).
dc.description.abstractStudy to examine the feasibility of using “real-world” office BP data obtained from electronic health records (EHR) to generate age-, sex- and height-specific BP percentiles for children.
dc.identifier.urihttps://pedsnet.org/metadata/handle/20.500.14642/945
dc.publisherPEDSnet
dc.relationOral Fludrocortisone, Drug Exposure
dc.relation.isreferencedbyMitsnefes MM, Maltenfort M, Denburg MR, Flynn JT, Schuchard J, et al. November 2023. "Derivation of paediatric blood pressure percentiles from electronic health records." _EBioMedicine_. 98:104885. <br>DOI: [10.1016/j.ebiom.2023.104885](https://doi.org/10.1016/j.ebiom.2023.104885)
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectStudy::Funded Study::PEDSnet Study
dc.subjectStudy::Funded Study::PCORnet Study
dc.subjectStudy::Cohort Study::Retrospective Study
dc.subject.meshBlood Pressure
dc.subject.meshBlood Pressure Determination
dc.subject.meshHypertension
dc.subject.meshVascular Diseases
dc.titleDerivation of Pediatric Blood Pressure References from Electronic Health Records
dspace.entity.typeStudy
local.subject.flatPEDSnet Data Source
local.subject.flatRetrospective Study
local.subject.flatCohort Study
project.startDate2023-11
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