Pediatric KIDney Stone (PKIDS) Care Improvement Network
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Abstract
Study to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones and to enable urologists to use techniques that result in the best outcomes for these surgeries.
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Description
Kidney stones are one of the fastest growing health conditions among children, adolescents, and young adults. The rapid increase over a short period of time has resulted in a large number of pediatric patients who require surgery to remove kidney stones with very little information available to guide selection of treatment options. There are three alternative approaches to remove kidney stones:
- Ureteroscopy (an endoscopic outpatient procedure)
- Shockwave lithotripsy (a noninvasive outpatient procedure)
- Percutaneous nephrolithotomy (a minimally invasive surgery with a short hospital stay)
This study will compares stone clearance (a primary determinant of painful stone passage, Emergency Department visits, and surgical retreatment) and patients’ experiences after ureteroscopy, shockwave lithotripsy and percutaneous nephrolithotomy for patients 8 to 21 years of age. The findings provide information that helps pediatric patients and their caregivers make individualized decisions on selecting the most appropriate surgical treatment option.
Study Aims
- To compare stone clearance for ureteroscopy (URS), shockwave lithotripsy (SWL), and percutaneous nephrolithotomy (PCNL).
- To compare patients’ experiences after URS, SWL, and PCNL
Study Design
This is a prospective cohort study. Investigators seek to compare stone clearance, re-treatment, and unplanned healthcare encounters for ureteroscopy, shockwave lithotripsy, and percutaneous nephrolithotomy.
Cohort Description
Inclusion Criteria:
- Males or females, 8-21 years of age, undergoing planned URS, SWL, or PCNL for the removal of at least one kidney and/or ureteral stone.
- Parental/guardian or participant (if ≥ 18 years old) permission (informed consent), and if appropriate, child assent
Exclusion Criteria: -Patients for whom conducting informed consent and baseline study procedures would confer additional risk (e.g. obstructing ureteral stone with fever requiring emergency surgery) and delay necessary immediate clinical care. -Parent/guardians or patients, who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
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Related Publications
Ellison JS, Lorenzo M, Beck H, Beck R, et al. April 2022. “Pediatric KIDney Stone Care ImprovementNetwork. Comparative effectiveness of paediatric kidney stone surgery (the PKIDS trial): study protocol for a patient-centred pragmatic clinical trial.” BMJ Open. 12(4):e056789.
DOI: 10.1136/bmjopen-2021-056789
Tasian GE, Maltenfort MG, Rove K, Ching CB, Ramachandra P, et al. June 2023. 'Ureteral Stent Placement Prior to Definitive Stone Treatment Is Associated With Higher Postoperative Emergency Department Visits and Opioid Prescriptions for Youth Having Ureteroscopy or Shock Wave Lithotripsy." J Urol. 209(6):1194-1201.
DOI: 10.1097/JU.0000000000003389
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