Pediatric KIDney Stone (PKIDS) Care Improvement Network

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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorTasian, Gregory
dc.contributor.authorAugelli, Brian
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2024-07-09T19:50:29Z
dc.date.available2024-07-09T19:50:29Z
dc.descriptionKidney stones are one of the fastest growing health conditions among children, adolescents, and young adults. The rapid increase over a short period of time has resulted in a large number of pediatric patients who require surgery to remove kidney stones with very little information available to guide selection of treatment options. There are three alternative approaches to remove kidney stones: - Ureteroscopy (an endoscopic outpatient procedure) - Shockwave lithotripsy (a noninvasive outpatient procedure) - Percutaneous nephrolithotomy (a minimally invasive surgery with a short hospital stay) This study will compares stone clearance (a primary determinant of painful stone passage, Emergency Department visits, and surgical retreatment) and patients' experiences after ureteroscopy, shockwave lithotripsy and percutaneous nephrolithotomy for patients 8 to 21 years of age. The findings provide information that helps pediatric patients and their caregivers make individualized decisions on selecting the most appropriate surgical treatment option. #### Study Aims 1. To compare stone clearance for ureteroscopy (URS), shockwave lithotripsy (SWL), and percutaneous nephrolithotomy (PCNL). 2. To compare patients' experiences after URS, SWL, and PCNL #### Study Design This is a prospective cohort study. Investigators seek to compare stone clearance, re-treatment, and unplanned healthcare encounters for ureteroscopy, shockwave lithotripsy, and percutaneous nephrolithotomy. #### Cohort Description Inclusion Criteria: - Males or females, 8-21 years of age, undergoing planned URS, SWL, or PCNL for the removal of at least one kidney and/or ureteral stone. - Parental/guardian or participant (if ≥ 18 years old) permission (informed consent), and if appropriate, child assent Exclusion Criteria: -Patients for whom conducting informed consent and baseline study procedures would confer additional risk (e.g. obstructing ureteral stone with fever requiring emergency surgery) and delay necessary immediate clinical care. -Parent/guardians or patients, who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
dc.description.abstractStudy to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones and to enable urologists to use techniques that result in the best outcomes for these surgeries.
dc.identifier.urihttps://pedsnet.org/metadata/handle/20.500.14642/722
dc.publisherPEDSnet
dc.relationAcetazolamide
dc.relationFurosemide
dc.relationHematuria
dc.relationOpioids
dc.relationTopiramate, Oral
dc.relationZonisamide, Oral
dc.relationSerum Albumin Measurement
dc.relationNephrotic Syndrome
dc.relationNephritis
dc.relation.isreferencedbyEllison JS, Lorenzo M, Beck H, Beck R, et al. April 2022. "Pediatric KIDney Stone Care ImprovementNetwork. Comparative effectiveness of paediatric kidney stone surgery (the PKIDS trial): study protocol for a patient-centred pragmatic clinical trial." _BMJ Open_. 12(4):e056789. <br>DOI: [10.1136/bmjopen-2021-056789](doi.org/10.1136/bmjopen-2021-056789)
dc.relation.isreferencedbyTasian GE, Maltenfort MG, Rove K, Ching CB, Ramachandra P, et al. June 2023. 'Ureteral Stent Placement Prior to Definitive Stone Treatment Is Associated With Higher Postoperative Emergency Department Visits and Opioid Prescriptions for Youth Having Ureteroscopy or Shock Wave Lithotripsy." _J Urol_. 209(6):1194-1201. <br>DOI: [10.1097/JU.0000000000003389](doi.org/10.1097/JU.0000000000003389)
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectStudy::Funded Study::PEDSnet Study
dc.subjectStudy::Investigator-Led Study
dc.subjectStudy::Funded Study::PKIDS Study
dc.subjectStudy::Cohort Study::Prospective Study
dc.subjectStudy::Clinical Study::Observational Study
dc.subject.meshKidney Calculi
dc.subject.meshNephrolithiasis
dc.subject.meshKidney Diseases
dc.subject.meshUrologic Diseases
dc.subject.meshUrinary Calculi
dc.titlePediatric KIDney Stone (PKIDS) Care Improvement Network
dspace.entity.typeStudy
local.admin.noteThe PM for this project is Ellen McQuaid. A big 5-year PCORI funded project that was awarded back in 2019. It is currently no longer active from a recruitment standpoint but the infrastructure is still being used.
local.subject.flatPEDSnet Data Source
local.subject.flatInvestigator-Led Study
local.subject.flatProspective Study
local.subject.flatCohort Study
project.endDate2021-10
project.startDate2019-11
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Pediatric KIDney Stone (PKIDS)
PCORnet® Designated Studies