Glomerular Disease, SNOMED-Only Codes

This concept set contains codes pertaining to glomerular disease, glomerulonephritis, nephritic syndrome, and nephrotic syndrome. It is intended to identify a cohort of patients with glomerular disease when incorporated into the computational phenotype originally developed and validated by Denburg et al 2019 (DOI: 10.1681/ASN.2019040365). Validation indicated that this computational phenotype had excellent classification accuracy across PEDSnet: sensitivity, 96% (95% CI, 94% to 97%); specificity, 93% (95% CI, 91% to 94%); positive predictive value (PPV), 89% (95% CI, 86% to 91%); negative predictive value, 97% (95% CI, 96% to 98%).

The computational phenotype identifies patients via two pathways: two or more glomerular inclusion diagnoses on different days of service, OR (one or more glomerular inclusion diagnosis AND one or more kidney biopsy which is not post-transplant). Codes flagged with “other_code_req” alone are not sufficient for a patient to be included in the cohort, i.e., these codes must be accompanied by another code without this flag or a kidney biopsy which is not post-transplant. Codes flagged with “neph_req” must be associated with a nephrology specialty visit.

The concept set was developed by mapping a list of ICD-9-CM codes provided by Michelle Denburg (clinician) to SNOMED. It is limited to SNOMED-CT-only diagnosis codes.