Hemolytic disease of the fetus and newborn (HDFN) otherwise known as erythroblastosis fetalis, is a disease in which fetal and neonatal erythrocytes are destroyed by maternal IgG alloantibodies. Before the first RhD immunoprophylaxis was introduced as a treatment in 1968, HDFN affected 1% of all newborns worldwide and resulted in a mortality rate of 50% […]
The National Evaluation System for health Technology Coordinating Center (NESTcc) is tasked to be a catalyst for the timely, reliable, and cost-effective development of real-world evidence (RWE) to enhance regulatory and clinical decision-making for medical devices. Real world data (RWD) reflects information relating to patient health status and the delivery of health care routinely collected […]
Once a relatively rare occurrence, the incidence rates of type 2 diabetes among children and adolescents continues to increase (SEARCH). In adults, oral hyperglycemic agents in conjunction with diet and exercise is an important treatment option used to control blood sugar and minimize long-term complications of the disease. However, there are relatively few approved medication […]
The Simons Foundation Powering Autism Research for Knowledge (hereinafter referred to as SPARK)Registry was established to recruit, engage, and retain a community of 50,000 individuals with ASD along with their family members in the United States to identify the causes of ASD, accelerate clinical research by providing the autism research community with a genotyped cohort […]