Health Services and Clinical Characteristics that Precede Diagnosis of Primary Hyperoxaluria Type 1
Primary hyperoxaluria (PH) encompasses 3 genetically distinct, autosomal-recessive, inborn errors of glyoxylate metabolism characterized by the over-production of oxalate, a highly insoluble metabolic endproduct that is eliminated mainly by the kidney. All 3 forms of PH exhibit some extent of overlap in the clinical manifestations, where overproduction of oxalate is a prominent observation. Renal oxalate […]