Principal Investigators: Michelle Denburg

Alternative Approaches for Managing Blood Pressure in Children with Chronic Kidney Disease (PRESERVE 2.0)

Research question: What clinic BP threshold should be targeted for kidney and cardiovascular protection in children with CKD? Should RAASi be first-line anti-hypertensive therapy for all children with CKD? Aims: Aim 1: Establish the pragmatic trial infrastructure by building on existing resources in PCORnet, PEDSnet, and PRESERVE.Aim 2: Compare the effects of conventional (<90th percentile), […]

P50 Projects – CHOP Pediatric Center for Excellence in Nephrology (PCEN)

With this renewal, the Pediatric Center of Excellence in Nephrology at the Children’s Hospital of Philadelphia (CHOP PCEN) will continue to facilitate extensive collaborative research around the causes, diagnoses, and treatment of childhood kidney diseases. Increasing efficiency and effectiveness, the CHOP PCEN will continue its focus to break down barriers to clinical trials implementation in […]

Preserving Kidney Function in Children with Chronic Kidney Disease

Chronic kidney disease, or CKD, is a health problem in which the kidneys don’t work well to remove waste from the blood. About half of all children with CKD also have high blood pressure, which increases their risk of kidney failure. When the kidneys fail, patients lose most of their kidney function and need dialysis […]

GLEAN Membranoproliferative Glomerulonephritis (MPGN) Project

C3 Glomerulopathy (C3G) and Immune Complex-associated Membranoproliferative Glomerulonephritis (IC-MPGN) are kidney diseases with different causes. C3G results from problems with the alternative complement pathway, while IC-MPGN is linked to the classical complement pathway due to immune complex formation. These conditions have often been grouped as types of membranoproliferative glomerulonephritis (MPGN) based on their appearance under […]