This is a retrospective observational study using a national sample with a pairwise treatment comparison in a so‐called ‘matrix model’ design. The aim of this study is to evaluate the comparative risks for serious infections, cardiovascular events, and incident cancer associated with biologics and non‐biologic therapies used for the treatment of adult and pediatric Autoimmune and inflammatory diseases, including rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthropathy, inflammatory bowel disease, juvenile arthritis, psoriasis, Systemic lupus erythematosus, and vasculitis.
Funding Source:
Participating PEDSnet Sites:
- Cincinnati Children’s Hospital Medical Center
- Children’s Hospital of Philadelphia
- Nationwide Children’s Hospital
- Seattle Children’s Hospital
- Nemours Children’s Health
Study Investigator:
Vasoactive Selection in Pediatric Septic Shock and the Use of Cardiac Point-of-Care Ultrasound: A Retrospective Registry Analysis Across Multicenter Pediatric Emergency Medicine and Pediatric Critical Care
Pediatric septic shock requires rapid recognition of cardiovascular failure and timely treatment to restore adequate tissue perfusion. Vasoactive medications are central to management, yet considerable uncertainty remains regarding the optimal first‑line agent. Although guidelines recommend tailoring vasoactive choice to a…
Childhood Neighborhood Exposures and Pediatric Multiple Sclerosis
Question 1: How can we identify children with MS using ICD-10 codes in the PEDSnet dataset Question 2: How do neighborhood exposures influence the risk of pediatric MS development Aim 1: Validate a computable phenotype to identify pediatric MS. Aim…
Preventing Suicide among Sexual and Gender Diverse Youth
Suicide is the second leading cause of death among young adults in the United States. Sexual and gender diverse young adults (SGDYA) are at particularly high risk. SGDYA includes individuals who are lesbian, gay, bisexual, transgender, queer, or of another…