The Urinary Stone Disease Hub (USDHub) is an innovative research initiative designed to advance the understanding, treatment, and prevention of urinary stone disease (USD), a condition that affects over 11% of the U.S. population and incurs healthcare costs exceeding $10 billion annually. USDHub aims to address key barriers in USD research, such as the lack of comprehensive, longitudinal data, by creating a large-scale, accessible data resource drawn from over 236,000 children and adults treated at 10 U.S. health systems participating in STAR and PEDSnet. The project will link structured electronic health record (EHR) data to clinically important information extracted from CT images, 24-hour urine chemistries, and unstructured clinical notes. By combining this rich data with input from patients and caregivers, USDHub will empower researchers to conduct impactful studies, including real-world comparative effectiveness research, clinical trials, and studies focused on underserved populations.
USDHub’s ultimate goal is to improve clinical care and outcomes for individuals with USD by providing an open, sustainable data resource that supports cutting-edge research. The findings will be shared through a public portal, pilot grants, and educational initiatives to enhance the USD research community’s capacity for impactful scientific discovery
Funding Source:
Participating PEDSnet Sites:
- Children’s Hospital of Philadelphia
- Cincinnati Children’s Hospital Medical Center
- Ann & Robert H. Lurie Children’s Hospital of Chicago
- Children’s National Hospital
- Nationwide Children’s Hospital
- Nemours Children’s Health
- Seattle Children’s Hospital
- Texas Children’s Hospital
Study Investigator:
Vasoactive Selection in Pediatric Septic Shock and the Use of Cardiac Point-of-Care Ultrasound: A Retrospective Registry Analysis Across Multicenter Pediatric Emergency Medicine and Pediatric Critical Care
Pediatric septic shock requires rapid recognition of cardiovascular failure and timely treatment to restore adequate tissue perfusion. Vasoactive medications are central to management, yet considerable uncertainty remains regarding the optimal first‑line agent. Although guidelines recommend tailoring vasoactive choice to a…
Childhood Neighborhood Exposures and Pediatric Multiple Sclerosis
Question 1: How can we identify children with MS using ICD-10 codes in the PEDSnet dataset Question 2: How do neighborhood exposures influence the risk of pediatric MS development Aim 1: Validate a computable phenotype to identify pediatric MS. Aim…
Preventing Suicide among Sexual and Gender Diverse Youth
Suicide is the second leading cause of death among young adults in the United States. Sexual and gender diverse young adults (SGDYA) are at particularly high risk. SGDYA includes individuals who are lesbian, gay, bisexual, transgender, queer, or of another…