Year of Study: 2026

Vasoactive Selection in Pediatric Septic Shock and the Use of Cardiac Point-of-Care Ultrasound: A Retrospective Registry Analysis Across Multicenter Pediatric Emergency Medicine and Pediatric Critical Care

Pediatric septic shock requires rapid recognition of cardiovascular failure and timely treatment to restore adequate tissue perfusion. Vasoactive medications are central to management, yet considerable uncertainty remains regarding the optimal first‑line agent. Although guidelines recommend tailoring vasoactive choice to a patient’s underlying physiology, substantial variation in practice persists across institutions. This variability may delay the […]

Childhood Neighborhood Exposures and Pediatric Multiple Sclerosis

Question 1: How can we identify children with MS using ICD-10 codes in the PEDSnet dataset Question 2: How do neighborhood exposures influence the risk of pediatric MS development Aim 1: Validate a computable phenotype to identify pediatric MS. Aim 2: Establish the relationship between neighborhood-level features and pediatric MS.

Preventing Suicide among Sexual and Gender Diverse Youth

Suicide is the second leading cause of death among young adults in the United States. Sexual and gender diverse young adults (SGDYA) are at particularly high risk. SGDYA includes individuals who are lesbian, gay, bisexual, transgender, queer, or of another sexual or gender identity that is not heterosexual or cisgender. This population experiences higher rates […]

Alternative Approaches for Managing Blood Pressure in Children with Chronic Kidney Disease (PRESERVE 2.0)

Research question: What clinic BP threshold should be targeted for kidney and cardiovascular protection in children with CKD? Should RAASi be first-line anti-hypertensive therapy for all children with CKD? Aims: Aim 1: Establish the pragmatic trial infrastructure by building on existing resources in PCORnet, PEDSnet, and PRESERVE.Aim 2: Compare the effects of conventional (<90th percentile), […]

The Declining Health of US Children

How has US children’s health evolved over time, and how does the health, resilience, and wellbeing of US children compare to that of 18 comparator countries in the Organization for Economic Cooperation and Development (OECD)? Aims: To evaluate temporal trends in US children’s health and to assess cross-national contrasts with 18 comparator countries in the […]

PEDSnet-Based Graph Embedding Pilot for Patient Similarity Modeling: FL-GNN Concept Validation Using Harmonized Pediatric Data

PEDSnet provides a harmonized, multi-institutional pediatric clinical dataset that enables cross-site research within a unified governance framework. However, traditional EHR analyses rely on diagnosis-based cohort definitions or tabular feature representations that do not fully capture the relational structure of longitudinal pediatric health data. We propose to leverage the Data Distillery Knowledge Graph (DDKG) to model […]

Identifying Pediatric Pancreatitis and Predicting Pancreatic Diabetes (T3cD)

Type 3c diabetes (T3cD) is a distinct form of diabetes related to diseases of the exocrine pancreas. In the setting of pancreatitis, T3cD affects 4-9% of children and is associated with long-term morbidity and increased mortality. T3cD is understudied especially in pediatrics, and we cannot yet predict which children will develop T3cD. My overall goal […]

Comparing Alternative Strategies for Pharmacologic Management of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

Should clinicians start treating children and youth diagnosed with ADHD with stimulant or nonstimulant classes of medications? Answering this question will inform clinicians of which class of medications should treatment start with, and for which patients, as well as which outcomes are best served by which medication class. By identifying patients suitable for non-stimulants, this […]

Ischemic Stroke Incidence and Risk Factors in Adults with Congenital Heart Disease

It is well known that adults with CHD have higher rates of stroke and stroke at younger ages, compared to the general population. We aim to better characterize this risk in a large US patient population, and to better understand the role of CHD-related and typical stroke risk factors to ultimately guide management strategies to […]