Determine the rate of clotting in central venous catheters (CVCs)

The purpose of this study is to assess the feasibility of conducting a study of central venous catheter-associated thrombosis in children using PEDSnet data.

Aim 1. Identify patients with evidence of CVC placement based on procedure or device data.
– Stratify cohort according to those with evidence/time of placement or not.
– Categorize CVC as implanted port, percutaneous CVC, or PICC.
– Categorize as temporary versus tunnelled percutaneous CVCs (when possible).
– Provide counts of persons by calendar year stratified by age category (0 – <2, 2 - <6, 6 - <12, 12 - <18), administrative sex, and administrative race/ethnicity. Also explore 0-6 months; 0-1 month Aim 2. Estimate dwell time for CVCs based on evidence of catheter removal or replacement (when available). - For each class of CVC noted above, provide mean, median, range, and IQR of dwell time for catheters having both placement and removal/replacement events. - Particularly interested in < vs. > 6 months.

Aim 3. Examine common diagnoses within 30 days of insertion and stratify prior results by whether there was a venous thromboembolism at removal.

Clinical Outcomes by Language of Care in Pediatric Oncology

Although language disparities in outcomes are well documented in general pediatrics and adult oncology, little is known in pediatric oncology. Patient or family language is not included in many multi- institutional databases and patient registries, limiting studies of language-based inequities…

Extreme weather impacts on children’s acute and chronic health outcomes; a multisite study with evaluation of vulnerabilities

The “Extreme Weather and Pediatric Health Outcomes” study investigates the impact of climate change-related extreme weather events, such as extreme heat and heavy rainfall, on children’s health across the United States. This innovative research aims to address critical knowledge gaps…

Characterization of Babies Born with Hemolytic Disease of the Fetus/Newborn (HDFN)

Hemolytic disease of the fetus and newborn (HDFN) otherwise known as erythroblastosis fetalis, is a disease in which fetal and neonatal erythrocytes are destroyed by maternal IgG alloantibodies. Before the first RhD immunoprophylaxis was introduced as a treatment in 1968,…

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