Detection of and Characteristics of Disease Progression in Children with CKD

The purpose of this study was to inform the design of a possible clinical trial in children with chronic kidney disease. Our goals were to use the PEDSnet EHR database to:
1. Identify a population of children ages 6 months to <18 years-old with chronic kidney disease defined by an eGFR in the range 30-89 ml/min and then, and
2. Characterize their longitudinal changes in kidney function over time in order to identify a sub-group of rapid progressors.

The study was done using PEDSnet’s database version 36 with data from November 2019.

Clinical Outcomes by Language of Care in Pediatric Oncology

Although language disparities in outcomes are well documented in general pediatrics and adult oncology, little is known in pediatric oncology. Patient or family language is not included in many multi- institutional databases and patient registries, limiting studies of language-based inequities…

Extreme weather impacts on children’s acute and chronic health outcomes; a multisite study with evaluation of vulnerabilities

The “Extreme Weather and Pediatric Health Outcomes” study investigates the impact of climate change-related extreme weather events, such as extreme heat and heavy rainfall, on children’s health across the United States. This innovative research aims to address critical knowledge gaps…

Characterization of Babies Born with Hemolytic Disease of the Fetus/Newborn (HDFN)

Hemolytic disease of the fetus and newborn (HDFN) otherwise known as erythroblastosis fetalis, is a disease in which fetal and neonatal erythrocytes are destroyed by maternal IgG alloantibodies. Before the first RhD immunoprophylaxis was introduced as a treatment in 1968,…

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