Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)


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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorForrest, Christopher
dc.contributor.authorDenburg, Michelle
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2026-02-27
dc.date.accessioned2024-07-09T19:50:29Z
dc.date.available2024-07-09T19:50:29Z
dc.descriptionThe purpose of PRESERVE is to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation. Specific aims of the study include enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients' lived experiences related to blood pressure management.
dc.description.abstractStudy intended to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD).
dc.identifier.urihttps://hdl.handle.net/20.500.14642/726
dc.publisherPEDSnet
dc.relation.isreferencedbyMitsnefes, Mark M. et al. 2023. "Derivation of paediatric blood pressure percentiles from electronic health records." __eBioMedicine__ , Volume 98, 104885. <br>DOI: [10.1016/j.ebiom.2023.104885](doi.org/10.1016/j.ebiom.2023.104885)
dc.relation.isreferencedbyDenburg, Michelle R. et al. 2023. "The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods". __Kidney Medicine__ , Volume 5, Issue 11, 100722. <br>DOI: [10.1016/j.xkme.2023.100722](doi.org/10.1016/j.xkme.2023.100722)
dc.relation.isreferencedbyRazzaghi H., Goodwin Davies A., Boss S., Bunnell H.T., Chen Y., et al. 2024. "Systematic data quality assessment of electronic health record data to evaluate study-specific fitness: Report from the PRESERVE research study." _PLOS Digital Health_ 3(6): e0000527. <br>DOI: [10.1371/journal.pdig.0000527](doi.org/10.1371/journal.pdig.0000527)
dc.relation.urihttps://github.com/PRESERVE-Coordinating-Center
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectPEDSnet Data Source
dc.subjectInvestigator-Led Study
dc.subjectGPC Data Source
dc.subjectPaTH Data Source
dc.subjectSTAR Data Source
dc.subjectRetrospective Study
dc.subjectCohort Study
dc.subjectObservational Study
dc.subjectClinical Study
dc.subjectPCORI-Funded Research
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshRenal Insufficiency
dc.subject.meshKidney Diseases
dc.subject.meshChronic Disease
dc.subject.meshUrogenital Diseases
dc.titlePreserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)
dc.title.alternative2021.FORC.PCORI.DCC
dspace.entity.typeStudy
local.admin.noteStudy PM: , Study Analysts: Amy Goodwin Davies
local.contributor.siteLeadPEDSnet Data Coordinating Center
local.contributor.sitesCincinnati Children�s Hospital Medical Center
local.contributor.sitesChildren�s Hospital of Philadelphia
local.contributor.sitesAnn & Robert H. Lurie Children�s Hospital of Chicago
local.contributor.sitesNationwide Children�s Hospital
local.contributor.sitesSeattle Children�s Hospital
local.contributor.sitesNemours Children�s Health
local.contributor.sitesStanford Children�s Health
project.endDate2024-06
project.startDate2021-07
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PCORnet® Designated Studies
PEDSnet Nephrology Research Program
Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) Project