Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)

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dc.contributorPatient-Centered Outcomes Research Institute
dc.contributor.authorForrest, Christopher
dc.contributor.authorDenburg, Michelle
dc.contributor.otherChildren's Hospital of Philadelphia
dc.date.accessioned2024-07-09T19:50:29Z
dc.date.available2024-07-09T19:50:29Z
dc.descriptionThe purpose of PRESERVE is to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation. Specific aims of the study include enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients' lived experiences related to blood pressure management.
dc.description.abstractStudy intended to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD).
dc.identifier.urihttps://hdl.handle.net/20.500.14642/726
dc.publisherPEDSnet
dc.relationhttps://pedsnet.org/metadata/handle/20.500.14642/585
dc.relation.isreferencedbyMitsnefes, Mark M. et al. 2023. "Derivation of paediatric blood pressure percentiles from electronic health records." __eBioMedicine__ , Volume 98, 104885. <br>DOI: [10.1016/j.ebiom.2023.104885](doi.org/10.1016/j.ebiom.2023.104885)
dc.relation.isreferencedbyDenburg, Michelle R. et al. 2023. "The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods". __Kidney Medicine__ , Volume 5, Issue 11, 100722. <br>DOI: [10.1016/j.xkme.2023.100722](doi.org/10.1016/j.xkme.2023.100722)
dc.relation.isreferencedbyRazzaghi H., Goodwin Davies A., Boss S., Bunnell H.T., Chen Y., et al. 2024. "Systematic data quality assessment of electronic health record data to evaluate study-specific fitness: Report from the PRESERVE research study." _PLOS Digital Health_ 3(6): e0000527. <br>DOI: [10.1371/journal.pdig.0000527](doi.org/10.1371/journal.pdig.0000527)
dc.relation.urihttps://github.com/PRESERVE-Coordinating-Center
dc.rightsa CC-BY 4.0 Attribution license.
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.subjectPEDSnet Data Source
dc.subjectInvestigator-Led Study
dc.subjectGPC Data Source
dc.subjectPaTH Data Source
dc.subjectSTAR Data Source
dc.subjectRetrospective Study
dc.subjectCohort Study
dc.subjectObservational Study
dc.subjectClinical Study
dc.subjectPCORI Funded Research
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshRenal Insufficiency
dc.subject.meshKidney Diseases
dc.subject.meshChronic Disease
dc.titlePreserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)
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project.endDate2024-06
project.startDate2021-07
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PCORnet® Designated Studies
Computable Phenotype Development
PRESERVE: Preserving Kidney Function in Children with Chronic Kidney Disease