Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)
dc.contributor | Patient-Centered Outcomes Research Institute |
dc.contributor.author | Forrest, Christopher |
dc.contributor.author | Denburg, Michelle |
dc.contributor.other | Children's Hospital of Philadelphia |
dc.date.accessioned | 2024-07-09T19:50:29Z |
dc.date.available | 2024-07-09T19:50:29Z |
dc.description | The purpose of PRESERVE is to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation. Specific aims of the study include enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients' lived experiences related to blood pressure management. |
dc.description.abstract | Study intended to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). |
dc.identifier.uri | https://pedsnet.org/metadata/handle/20.500.14642/726 |
dc.publisher | PEDSnet |
dc.relation | Deflazacort, Oral |
dc.relation | Kidney Dialysis |
dc.relation | Outpatient Visits |
dc.relation | Hematology, Facility |
dc.relation | Cardiology, Provider |
dc.relation | Anesthesia |
dc.relation | Gestational Age |
dc.relation | Height |
dc.relation | Kidney Transplant |
dc.relation | Nephrotoxic Chemotherapy |
dc.relation | Primary Care, Provider |
dc.relation | Oncology, Provider |
dc.relation | Weight |
dc.relation | Oncology, Facility |
dc.relation | Nephrology, Facility |
dc.relation | Calcium Channel Blockers |
dc.relation | Diastolic Blood Pressure Measurement |
dc.relation | Urology, Provider |
dc.relation | Body Mass Index Calculated by Source |
dc.relation | Systolic Blood Pressure Measurement |
dc.relation | Antineoplastics |
dc.relation | Nephrology, Provider |
dc.relation | Chemotherapy |
dc.relation | Primary Care, Facility |
dc.relation | Hematology, Provider |
dc.relation | Birth Weight |
dc.relation | Fludrocortisone, Oral |
dc.relation | Inpatient Visits |
dc.relation | Urology, Facility |
dc.relation | Chronic Kidney Disease, Stages 2 and 3 |
dc.relation | ACE Inhibitors |
dc.relation | Angiotensin Receptor Blockers |
dc.relation | Beta Blockers |
dc.relation | Loop Diuretics |
dc.relation | Methods for Taking Blood Pressure |
dc.relation | Serum Bicarbonate Measurement |
dc.relation | Serum Creatinine Measurement |
dc.relation | Serum Cystatin Measurement |
dc.relation | Serum Potassium Measurement |
dc.relation | Stomatitis |
dc.relation | Thiazides |
dc.relation | Urinary Tract Infection |
dc.relation | Urine Creatinine Measurement |
dc.relation | Urine Protein to Creatinine Ratio Measurement |
dc.relation | Urine Protein, Qualitative Measurement |
dc.relation | Urine Protein, Quantitative Measurement |
dc.relation | Dizziness |
dc.relation | Elevated Blood Pressure, Distinct from Hypertension |
dc.relation | Renal Artery Stenosis |
dc.relation | Polycystic Kidney Disease (PKD) |
dc.relation | Congenital Anomalies of the Kidneys and Urinary Tracts (CAKUT) |
dc.relation | Gastrointestinal Symptoms |
dc.relation | Hypertension, Excluding Pregnancy-Related Hypertension |
dc.relation | Kidney Transplant |
dc.relation | Glomerular Disease |
dc.relation | Glomerular Disease |
dc.relation | Tonsillitis |
dc.relation | Ambulatory Blood Pressure Monitoring |
dc.relation | Hypotension |
dc.relation | Chronic Kidney Dialysis |
dc.relation | Edema |
dc.relation | Kidney Biopsy |
dc.relation | Emergency Visits |
dc.relation | Headache for PRESERVE |
dc.relation | Pericarditis |
dc.relation | Hypertension |
dc.relation | Cough |
dc.relation | Hair Loss |
dc.relation | Cancer |
dc.relation | Nocturnal Enuresis |
dc.relation | Respiratory Infections |
dc.relation | Pyelonephritis |
dc.relation | Cardiology, Facility |
dc.relation | Pregnancy |
dc.relation | Kidney Transplant |
dc.relation | Chronic Dialysis |
dc.relation.isreferencedby | Mitsnefes, Mark M. et al. 2023. "Derivation of paediatric blood pressure percentiles from electronic health records." __eBioMedicine__ , Volume 98, 104885. <br>DOI: [10.1016/j.ebiom.2023.104885](doi.org/10.1016/j.ebiom.2023.104885) |
dc.relation.isreferencedby | Denburg, Michelle R. et al. 2023. "The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods". __Kidney Medicine__ , Volume 5, Issue 11, 100722. <br>DOI: [10.1016/j.xkme.2023.100722](doi.org/10.1016/j.xkme.2023.100722) |
dc.relation.isreferencedby | Razzaghi H., Goodwin Davies A., Boss S., Bunnell H.T., Chen Y., et al. 2024. "Systematic data quality assessment of electronic health record data to evaluate study-specific fitness: Report from the PRESERVE research study." _PLOS Digital Health_ 3(6): e0000527. <br>DOI: [10.1371/journal.pdig.0000527](doi.org/10.1371/journal.pdig.0000527) |
dc.relation.uri | https://github.com/PRESERVE-Coordinating-Center |
dc.rights | a CC-BY 4.0 Attribution license. |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ |
dc.subject | Study::Funded Study::PEDSnet Study |
dc.subject | Study::Investigator-Led Study |
dc.subject | Study::Funded Study::PCORnet Study |
dc.subject.mesh | Renal Insufficiency, Chronic |
dc.subject.mesh | Renal Insufficiency |
dc.subject.mesh | Kidney Diseases |
dc.subject.mesh | Chronic Disease |
dc.title | Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) |
dspace.entity.type | Study |
local.subject.flat | PEDSnet Data Source |
local.subject.flat | Investigator-Led Study |
local.subject.flat | GPC Data Source |
local.subject.flat | PaTH Data Source |
local.subject.flat | STAR Data Source |
local.subject.flat | Retrospective Study |
local.subject.flat | Cohort Study |
local.subject.flat | Observational Study |
local.subject.flat | Clinical Study |
local.subject.flat | PCORI Funded Research |
project.endDate | 2024-06 |
project.startDate | 2021-07 |
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