Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)
Study Dates
Last Modified
Tags
Publisher
Abstract
Study intended to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD).
Affiliation(s)
Funder(s)
Provenance
Description
The purpose of PRESERVE is to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation. Specific aims of the study include enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients’ lived experiences related to blood pressure management.
Development Code
Vocabulary
Clinical Subjects
Related Publications
Mitsnefes, Mark M. et al. 2023. “Derivation of paediatric blood pressure percentiles from electronic health records.” eBioMedicine , Volume 98, 104885.
DOI: 10.1016/j.ebiom.2023.104885
Denburg, Michelle R. et al. 2023. “The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods”. Kidney Medicine , Volume 5, Issue 11, 100722.
DOI: 10.1016/j.xkme.2023.100722
Razzaghi H., Goodwin Davies A., Boss S., Bunnell H.T., Chen Y., et al. 2024. “Systematic data quality assessment of electronic health record data to evaluate study-specific fitness: Report from the PRESERVE research study.” PLOS Digital Health 3(6): e0000527.
DOI: 10.1371/journal.pdig.0000527
Creative Commons license
