Study

Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)


Study Dates
2021-07 - 2024-06
Principal Investigator
Forrest, Christopher , Denburg, Michelle
Affiliation
Children's Hospital of Philadelphia
Sponsor Site
PEDSnet Data Coordinating Center
PEDSnet Study ID
2021.FORO.PCORI.DCC.200

Study intended to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD).

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Funding

This research was made possible through the generous support of Patient-Centered Outcomes Research Institute. The statements presented in this work are solely the responsibility of the author(s) and do not necessarily represent the views of PCORI, its Board of Governors, or its Methodology Committee.

Creative Commons license

a CC-BY 4.0 Attribution license.
Except where otherwised noted, this item's license is described as a CC-BY 4.0 Attribution license.

Publisher

PEDSnet

Project Description

The purpose of PRESERVE is to provide new knowledge to inform shared decision-making regarding blood pressure management for pediatric chronic kidney disease (CKD). Hypertension occurs in 50% of children with CKD and is a major risk factor for decline in kidney function. Several clinical practice guidelines have offered recommendations for blood pressure management in pediatric CKD; however, clinical trial and large-scale observational data are limited, leading to a weak evidence base and substantial practice variation. Specific aims of the study include enhancing the PCORnet Common Data Model for pediatric and rare kidney disease research; describing and examining the effectiveness of consistent blood pressure and urine protein monitoring for preserving kidney function; comparing the effectiveness of BP medication strategies for preserving kidney function; and assess patients’ lived experiences related to blood pressure management.

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