Childhood Neighborhood Exposures and Pediatric Multiple Sclerosis
Question 1: How can we identify children with MS using ICD-10 codes in the PEDSnet dataset Question 2: How do neighborhood exposures influence the risk of pediatric MS development Aim 1: Validate a computable phenotype to identify pediatric MS. Aim…
Ischemic Stroke Incidence and Risk Factors in Adults with Congenital Heart Disease
It is well known that adults with CHD have higher rates of stroke and stroke at younger ages, compared to the general population. We aim to better characterize this risk in a large US patient population, and to better understand…
Long-term Neurodevelopmental Effects in Neonates Following Treatment with Lacosamide
The Neurodevelopmental Outcomes Study is a retrospective, observational cohort study designed to compare the long-term neurocognitive outcomes of neonates treated with lacosamide versus other antiseizure medications (ASMs) for neonatal seizures. Neonatal seizures, which occur in 1.4 to 3.6 per 1,000…
Creation of a Computable Phenotype in Childhood- Onset Arterial Ischemic Stroke (CAIS)
Previous studies of administrative databases often misclassified up to 73% of strokes by just using diagnosis codes. This study will develop and validate a computable phenotype that can more accurately identify patients in our multi-institution database using clinical and lab…
Long-term Neurocognitive Effects in Neonates Following Treatment with Lacosamide
The Neurocognitive Developmental Outcomes Study is a retrospective, observational cohort study designed to compare the long-term neurocognitive outcomes of neonates treated with lacosamide versus other antiseizure medications (ASMs) for neonatal seizures. Neonatal seizures, which occur in 1.4 to 3.6 per…
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