Vasoactive Selection in Pediatric Septic Shock and the Use of Cardiac Point-of-Care Ultrasound: A Retrospective Registry Analysis Across Multicenter Pediatric Emergency Medicine and Pediatric Critical Care
Pediatric septic shock requires rapid recognition of cardiovascular failure and timely treatment to restore adequate tissue perfusion. Vasoactive medications are central to management, yet considerable uncertainty remains regarding the optimal first‑line agent. Although guidelines recommend tailoring vasoactive choice to a…
The Declining Health of US Children
How has US children’s health evolved over time, and how does the health, resilience, and wellbeing of US children compare to that of 18 comparator countries in the Organization for Economic Cooperation and Development (OECD)? Aims: To evaluate temporal trends…
PEDSnet-Based Graph Embedding Pilot for Patient Similarity Modeling: FL-GNN Concept Validation Using Harmonized Pediatric Data
PEDSnet provides a harmonized, multi-institutional pediatric clinical dataset that enables cross-site research within a unified governance framework. However, traditional EHR analyses rely on diagnosis-based cohort definitions or tabular feature representations that do not fully capture the relational structure of longitudinal…
Investigating timing of diagnosis and equitable care in children with Turner syndrome
PEDSNet data will be used to identify temporal changes in timing of diagnosis following updated Turner syndrome guidelines in 2017, in addition to association of race, ethnicity and insurance status to timing of diagnosis. Existing dataset of children with Turner…
Development and Validation of an Equitable Computable Phenotype for Classifying Pediatric Sleep Deficiency in Electronic Health Records
Sleep deficiency remains one of the most prominent and unaddressed public health concerns in pediatric healthcare settings. Pediatric sleep disparities are prominent across minoritized racial subpopulations in the dimensions of sleep duration, timing, alertness, behaviors, and quality/disorders. Despite the evidence…
Vision Screening in Young Children with Autism
Children with Autism Spectrum Disorder (ASD) have greater unmet healthcare needs compared with typically developing peers, including delays in seeking medical care, inadequate insurance coverage, and inability to access necessary therapy services. Many children with ASD do not receive recommended…
Development and Validation of an Equitable Computable Phenotype for Classifying Pediatric Sleep Deficiency in Electronic Health Records
Sleep deficiency remains one of the most prominent and unaddressed public health concerns in pediatric healthcare settings. Pediatric sleep disparities are prominent across minoritized racial subpopulations in the dimensions of sleep duration, timing, alertness, behaviors, and quality/disorders. Despite the evidence…
Barriers in the access to expensive genetic therapies for spinal muscular atrophy
Although the inherited neuromuscular disease spinal muscular atrophy is considered a rare disease, it has been on the forefront of genetic therapies research, with three therapies receiving FDA approval since 2016. Spinal muscular atrophy is an autosomal recessive loss of…
Skeletal and Cranial Growth Among Children with Achondroplasia
Achondroplasia, the most common form of disproportionate short stature, is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene. Affected children may experience severely impaired foramen magnum growth during the first years of life, which may…
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