Study Funding Source: Industry
NESTR1: Comparative Effectiveness of Alternative Approaches for Wound Closure
There are three methods for closure of wounds that result from surgeries or trauma: sutures, staples, and skin adhesives. The purpose of this project is to compare each of these skin closure approaches in terms of the types of skin wounds and the patient populations they are used for along with short-term outcomes, such as […]
Pharmacokinetics in Neonates Exposed to Lacosamide
Seizures are one of the most common neurologic emergencies in neonates, arising in ~3/1000term live births and are associated with significant mortality and neuro-developmental disability (Soul et al, 2018). In contrast to seizures in older children, most neonatal seizures result from acute symptomatic etiologies rather than epilepsy. The most common etiologies include neonatal encephalopathy caused […]
Creation of Computable Alopecia Areata Phenotype to Evaluate Epidemiology of Pediatric Alopecia Areata and Potential Health Care Disparities in care among children living with Alopecia Areata
Alopecia areata is a chronic, T-cell-mediated disease that targets hair follicles and causes patches of nonscarring hair loss. Despite being relatively common (prevalence of 1-2%), current studies on alopecia areata epidemiology are conflicting, and no large-scale epidemiologic studies have been performed in children in the United States to date. It is still unclear if prevalence […]
Exploring PedsNet Capabilities in T2 Diabetes in the US (Invokana)
Once a relatively rare occurrence, the incidence rates of type 2 diabetes among children and adolescents continues to increase (SEARCH). In adults, oral hyperglycemic agents in conjunction with diet and exercise is an important treatment option used to control blood sugar and minimize long-term complications of the disease. However, there are relatively few approved medication […]
Retrospective cohort study evaluating treatment pathways through care and potential adverse events in neonatal seizures
Seizures are one of the most common neurologic emergencies in neonates, arising in ~3/1000 term live births and are associated with significant mortality and neuro-developmental disability (Soul et al, 2018). In contrast to seizures in older children, most neonatal seizures result from acute symptomatic etiologies rather than epilepsy. The most common etiologies include neonatal encephalopathy […]
Pediatric Glomerular Disease Learning Network
The goal of this study is to create a sustainable and expandable Pediatric Glomerular Disease Learning Network to address fundamental limitations of current observational cohorts and registries and focus on practice pattern variation, observational outcomes and comparative effectiveness research, and ultimately pragmatic clinical trials. The objectives of this study are: to develop and validate a […]