Study Funding Source: Institutional

A Learning Health Systems Approach to Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in Children

Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an understudied, chronic inflammatory disease in children for which only half of children reach remission by 6-months and approximately 7% do not survive past young adulthood. Due to its rarity, there are no large observational studies or randomized control trials to guide management. Additionally, there is a known discordance […]

Implementing Minoritized Community Engagement with Pediatric Dermatology

Dermatology care is nearly non-existent for American Indian and Alaska Native (AIAN) youth. The Indian Health Service (IHS) currently employs a single dermatologist for more than 2 million patients, which suggests that AIAN youth face substantial barriers to accessing dermatology. Limited treatment for skin disease may explain health disparities in prevalence and severity of skin […]

Clinical Characteristics of Adolescents Hospitalized for Eating Disorders 2010-2020

This study will gather more data and characteristics of pediatric patients with eating disorders. The intention is to use PEDSnet data to gather demographic (age, sex, insurance status) as well as clinical (cardiac complications such as arrhythmias, bradycardia) from patients with hospitalizations for eating disorders from 2010-2020.

Adjunctive Therapies in Pediatric Severe Sepsis and Septic Shock: An Analysis through Multi-Center Linkage of the Virtual Pediatric Systems and PEDSnet

Pediatric severe sepsis, an overwhelming systemic inflammatory response to infection, is a leading cause of mortality in pediatric intensive care units (PICUs) worldwide. Despite decades of sepsis research, the main therapies available for the management of sepsis essentially remain goal-directed fluid resuscitation, timely antibiotic administration, and supportive care for organ dysfunction. Additional adjunctive therapies including […]

Unanticipated Consequences of Proton Pump Inhibitor Use

This study investigates whether genetic variation in CYP2C19 contributes to proton pump inhibitor-associated infections and chronic illness exacerbations in children. Study aims include: 1) To compare rates of infection in healthy and obese children, and children with chronic illnesses of asthma and inflammatory bowel disease before and during treatment with proton pump inhibitors; 2) To […]

Comparative Effectiveness of Narrow Versus Broad-Spectrum Antibiotic Use On ED Revisit Rates In Pediatric Pneumonia

We propose to evaluate the impact of antibiotic prescribing patterns on hospital revisit rates among children with community acquired pneumonia. 1) Among children discharged from emergency department (ED) with Community-Acquired Pneumonia (CAP), does antibiotic prescribing patterns impact 3-day and 7-day revisit rates? Hypothesis 1: Children receiving amoxicillin do not have higher ED revisit rates compared […]