Institutional

Study Funding Source: Institutional

Vasoactive Selection in Pediatric Septic Shock and the Use of Cardiac Point-of-Care Ultrasound: A Retrospective Registry Analysis Across Multicenter Pediatric Emergency Medicine and Pediatric Critical Care

Pediatric septic shock requires rapid recognition of cardiovascular failure and timely treatment to restore adequate tissue perfusion. Vasoactive medications are central to management, yet considerable uncertainty remains regarding the optimal first‑line agent. Although guidelines recommend tailoring vasoactive choice to a patient’s underlying physiology, substantial variation in practice persists across institutions. This variability may delay the […]

The Declining Health of US Children

How has US children’s health evolved over time, and how does the health, resilience, and wellbeing of US children compare to that of 18 comparator countries in the Organization for Economic Cooperation and Development (OECD)? Aims: To evaluate temporal trends in US children’s health and to assess cross-national contrasts with 18 comparator countries in the […]

Acute Kidney Injury Phenotypes and Long-Term Major Adverse Kidney Events

The purpose of our study is to evaluate the long-term outcomes after AKI in critically ill children and identify the risk factors associated with these outcomes. Our central hypothesis is that long-term major adverse kidney events (MAKE; a composite of death, dialysis dependence or persistent kidney dysfunction) is common after AKI in critically ill patients, […]

Distinguishing clinical manifestations, treatment, and long-term outcomes of pseudohypoaldosteronism (PHA) vs congenital adrenal hyperplasia (CAH)

Pseudohypoaldosteronism can be a potentially fatal disease involving a disruption in the mineralocorticoid aldosterone. Given aldosterone’s role in maintaining fluid homeostasis, an imbalance results in hypokalemia, hypernatremia, and metabolic acidosis in newborns. The clinical presentation of pseudohypoaldosteronism mirrors congential adrenal hyperplasia (CAH), often resulting in a misdiagnosis and delayed treatment of PHA. We hope to […]

Inconsistent Influenza Vaccinators: Population Characteristics and a Patient Centered Pilot Study ​

The “Population Characteristics of Inconsistent Influenza Vaccinators” study, part of the PEDSnet Scholars project, aims to explore and characterize pediatric patients who exhibit inconsistent influenza vaccination behaviors. Inconsistent vaccinators—children who receive the influenza vaccine in some seasons but not others—represent a significant portion of the population yet remain understudied. This research seeks to understand the […]

Examining the Relationship between Substance Use and Suicide among Pediatric Patients: Exploring differences by Race and Ethnicity

Individuals who use substances are at high risk for suicide and suicide attempts. In fact, substance use disorder is documented as an important risk factor for suicidality (SUDs; Poorolajal et al., 2016; Armoon et al., 2021), including among adolescents (e.g., Kelly et al., 2004). However, fewer studies have examined substance use at varying levels of […]

Identification and Treatment of Attention-Deficit/Hyperactivity Disorder Diagnosis or Related Symptoms in Children 2 to 5-Years-Old

Attention-Deficit/Hyperactivity Disorder (ADHD), the most prevalent childhood neurobehavioral disorder, is increasingly being identified in young children before they enter school. Identifying and treating ADHD symptoms in preschool-age children is important for mitigating the negative effects of this disorder on social-emotional development and school readiness. Most US children with ADHD are treated by their primary care […]

Defining the epidemiology and impacts of iron overload in children undergoing bone marrow transplants for hematological disorders.

This study focuses on iron overload in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) for non-malignant blood disorders (NMBD). In recent years, HSCT for NMBD has increased, but little data exists on how iron overload, often caused by blood transfusions, impacts post-transplant outcomes. The study aims to assess the prevalence of iron overload in […]

The Effects of Dupilumab on the development of T1 associated disease

This study investigates whether dupilumab, a Type 2 inflammation-blocking agent commonly used to treat allergic diseases, is associated with an increased risk of developing Type 1 diseases in children. Using the PEDSnet electronic health record network, researchers conducted a multicenter retrospective cohort study involving children aged 6-17 with asthma and/or atopic dermatitis, comparing those treated […]

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