Headache has been one of the top three causes of disability adjusted life years for the past three decades among adolescents and young adults. The inspiration for this research comes from the disproportionately higher burden that falls on girls and women starting in puberty, when prevalence rises more quickly in girls than boys, then continues […]
Jennifer Kusma, MD, MS is a pediatrician and junior clinical investigator focused on improving the 3 evidence-base for the health care policy and access for children with special health care needs (CSHCN). Dr. 4 Kusma’s long-term career goal is to become an independent physician-investigator who works in cross- 5 disciplinary teams to evaluate evidence-based health care policy […]
Distributed health data networks (DHDNs) that leverage electronic health records (EHRs) (e.g., eMerge, pSCANNER, PEDSnet) have gained substantial interests in recent years, as they a) eliminate the need to create, maintain, and secure access to central data repositories, b) minimize the need to disclose protected health information outside the data-owning entity, and c) mitigate many […]
With this renewal, the Pediatric Center of Excellence in Nephrology at the Children’s Hospital of Philadelphia (CHOP PCEN) will continue to facilitate extensive collaborative research around the causes, diagnoses, and treatment of childhood kidney diseases. Increasing efficiency and effectiveness, the CHOP PCEN will continue its focus to break down barriers to clinical trials implementation in […]
This study aims to expand understanding of how crystalloid fluid impacts sepsis survivors’ lives beyond 30 days. Aim 1: Determine the most effective crystalloid fluid choice to minimize sepsis-induced AKI and CKD in PRoMPT BOLUS trial participants Aim 2: Measure the real-world impact of crystalloid fluid on sepsis-induced AKI and CKD
Pragmatic trials and comparative effectiveness research often require causal inference methods to establish cause-effect relationships between interventions and outcomes. With treatments that can change over time, it is crucial to account for time-dependent confounders to accurately estimate treatment effects. Statistical methods to do so have not been developed for recurrent time-to-event outcomes, although such outcomes […]
Investigators from two of the nation’s top health research institutions, Weill Cornell Medicine (WCM) and Children’s Hospital of Philadelphia (CHOP), are spearheading a new study aimed at understanding more about long-haul COVID-19. Dr. Christopher Forrest, professor of pediatrics and health care management at CHOP and principal investigator (PI) of the PEDSnet Clinical Research Network (CRN); […]
This study is specifically directed at developing an accurate and scalable approach to facilitate early detection of coronavirus infection and deterioration in the pediatric population. We propose to use state-of-the-art artificial intelligence (AI) technologies, including natural language processing (NLP) and machine learning, to analyze research articles, identify pertinent risk factors, and predict risk of coronavirus […]
This study examined the prevalence of medical diagnoses in youth with sex chromosome aneuploidy (SCA) compared to matched controls in a large pediatric health learning system (PEDSnet). There was a significantly higher relative risk of having diagnoses within the Cardiovascular, Endocrine, Mental Health, and Nervous systems for all SCAs compared to their matched controls, and […]