Hypertension (HTN) is the primary cause of cardiovascular disease (CVD) in the United States. Individuals with the greatest risk of developing HTN in adulthood have elevated blood pressure (BP) and accelerated BP trajectories in childhood and adolescence, beginning at 9 years of age when BP tracking occurs, Social determinants of health (SDoH) drive 80% of population health outcomes. The impact of exposure to social deprivation on hypertensive risk factor development in early life has not been fully elucidated. Our central hypothesis is that exposure to greater deprivation (higher ADI) is associated with a “high stable” or “increasing” SBP percentile trajectory compared to exposure to lesser deprivation (lower ADI), during childhood and adolescence.
Aim 1: To determine if there is a relationship between area deprivation index [ADI=1 least to ADI=100 most deprived] and SBP percentile trajectory in children.
Aim 2: To determine the relationship between area deprivation and SBP percentile trajectories in males and females, according to race and ethnicity.
Aim 3: To determine the impact of improved ADI on SBP percentile trajectory.
Prediction Modeling of the Impact of Area Deprivation on Systolic Blood Pressure Trajectory in Youth
Funding Source:
Participating PEDSnet Sites:
- Cincinnati Children’s Hospital Medical Center
- Children’s Hospital of Philadelphia
- Ann & Robert H. Lurie Children’s Hospital of Chicago
- Nationwide Children’s Hospital
- Seattle Children’s Hospital
- Nemours Children’s Health
- Texas Children’s Hospital
Study Investigator:
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