Adjunctive Therapies in Pediatric Severe Sepsis and Septic Shock: An Analysis through Multi-Center Linkage of the Virtual Pediatric Systems and PEDSnet
Pediatric severe sepsis, an overwhelming systemic inflammatory response to infection, is a leading cause of mortality in pediatric intensive care units (PICUs) worldwide. Despite decades of sepsis research, the main therapies available for the management of sepsis essentially remain goal-directed…
The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study: Developing a Roadmap for De-Implementation
Bronchiolitis is a common respiratory condition that primarily affects infants and young children, typically occurring in children under two years old. It is characterized by wheezing, coughing, and difficulty breathing. Long-term effects can include recurrent wheezing or increased risk of…
CDC BMI Trajectories Analysis in PEDSnet
PEDSnet fulfilled a feasibility query in 2017 submitted by the CDC to assess availability of data to describe BMI trajectories of children. A major impetus for the request is a dearth of longitudinal BMI data that is current. The CDC…
Diuretic and Inhaled Corticosteroid Treatment at US Children’s Hospitals
Bronchopulmonary dysplasia (BPD), the major chronic lung disease of infancy, affects approximately half of infants born at ≤28-weeks gestation and persists as a leading cause of mortality and respiratory impairments among preterm infants. BPD is commonly measured at 36-weeks post…
Growing National Rare Pediatric Brain Tumor Biobank Specimens From a National LHS
This research focuses on the intersection of two national longitudinal health data collection projects: The Children’s Brain Tumor Tissue Consortium (CBTTC) and the PEDSnet Clinical Data Research Network (CDRN) with the intention of harmonizing the two national projects as they…
GLEAN Membranoproliferative Glomerulonephritis (MPGN) Project
C3 Glomerulopathy (C3G) and Immune Complex-associated Membranoproliferative Glomerulonephritis (IC-MPGN) are kidney diseases with different causes. C3G results from problems with the alternative complement pathway, while IC-MPGN is linked to the classical complement pathway due to immune complex formation. These conditions…
GLEAN Membranoproliferative Glomerulonephritis (MPGN) Project
C3 Glomerulopathy (C3G) and Immune Complex-associated Membranoproliferative Glomerulonephritis (IC-MPGN) are kidney diseases with different causes. C3G results from problems with the alternative complement pathway, while IC-MPGN is linked to the classical complement pathway due to immune complex formation. These conditions…
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