Using EHR Data to Evaluate the Burden of Diabetes Mellitus in a National Network of Children’s Hospital Health Systems
Diabetes mellitus is a group of disorders characterized by hyperglycemia resulting from defects in insulin production, insulin action, or both. In children and adolescents 0-17 years-old, pediatric diabetes mellitus (PDM) is one of the more common chronic diseases. Mounting evidence…
COVID-19 Electronic Healthcare Data Initiative
PCORnet®, the National Patient-Centered Clinical Research Network, has been working actively to build infrastructure to support COVID-19 surveillance across its sites. Since early in the COVID-19 pandemic, PCORnet has implemented critical changes to its data infrastructure to allow for capture of information…
Medications and Weight Gain Across the Lifecourse in PCORnet
Several prior studies have assessed whether individual prescription medications are associated with weight gain and increased risk for conditions such as diabetes and high cholesterol. These negative health effects from medications are a particular concern for medications used to treat…
Comparative effectiveness of treatments for recurrent focal segmental glomerulosclerosis in pediatric kidney transplantation
Background Recurrence of focal segmental glomerulosclerosis (FSGS) or steroid-resistant nephrotic syndrome (SRNS) after kidney transplant leads to significant morbidity and potentially earlier allograft loss. To date, however, reported rates, risk factors, and treatment outcomes have varied widely. Methods We applied…
National estimate for sterile injectable chemotherapy use for pediatric cancer patients
Cancer afflicts approximately 15,000 children annually in the United States. In recent years, drug shortages for sterile injectable chemotherapies have occurred in the United States. This study seeks to estimate the amount of sterile chemotherapy used each year in the…
Utilization of PEDSnet to create a novel classifier for children with nephrotic syndrome using aggregated clinical and genetic testing data
Nephrotic syndrome (NS) is a leading cause of acquired end-stage kidney disease (ESKD) in children. The incidence of NS is approximately 2-5 per 100,000 children and its pathogenesis is not fully understood. Children with NS are classified based on: 1)…
A Two-Stage Meta-Regression Framework for Precision Medicine Using Data from Clinical Data Research Networks
Pediatric Chron’s Disease (PCD) is a chronic inflammatory bowel disease (IBD) that has been recognized as one of the most important chronic diseases that affect children and adolescents, with increasing incidence in youth of varying ages. Literature presents gaps in…
A Distributed Learning Framework for Integrating Evidence in Clinical Research Networks
Rare events such as gastrointestinal bleeding, clinical sites independently often contain insufficient number of cases leading to challenges in characterizing the effect sizes of risk factors for adverse events and conducting accurate risk prediction. Individual patient-level information at each site…
How Accurate Are PCORnet® Data for Measures of Children’s Healthcare Quality? — A PCORnet® Study
Health systems use quality measures to assess how well they deliver care to patients. These measures require accurate data. Health systems often do a manual medical chart review to get accurate data. To do a manual review, staff combine data…
Exploring PedsNet Capabilities in T2 Diabetes in the US (Invokana)
Once a relatively rare occurrence, the incidence rates of type 2 diabetes among children and adolescents continues to increase (SEARCH). In adults, oral hyperglycemic agents in conjunction with diet and exercise is an important treatment option used to control blood…
Anti-TNF Monotherapy versus Combination Therapy with Low Dose Methotrexate in Pediatric Crohn’s Disease (The COMBINE Study)
Crohn’s disease causes inflammation in the intestines and stomach, leading to long-term diarrhea and stomach pain. It can also lead to growth problems and lower quality of life. For children, the illness can get worse over time.Doctors treat Crohn’s disease…
Retrospective cohort study evaluating treatment pathways through care and potential adverse events in neonatal seizures
Seizures are one of the most common neurologic emergencies in neonates, arising in ~3/1000 term live births and are associated with significant mortality and neuro-developmental disability (Soul et al, 2018). In contrast to seizures in older children, most neonatal seizures…
AHRQ Child Health Quality Program (CHeQ)
The Institute for Child Health Policy at the University of Florida (UF-ICHP) currently measures and evaluates quality of care for almost 1 in 5 children enrolled in Medicaid and the Children’s Health Insurance Program (CHIP) in the US. We collaborate…
Skeletal Outcomes in Children and Young Adults with Glomerular Disease
Children and adolescents with glomerular disease have unique and potentially modifiable risk factors for compromised bone health. As delineated by the applicant’s K23 project, glomerular disease is associated with multiple disturbances in vitamin D homeostasis and mineral metabolism, independent of…
Colectomy for Pediatric Ulcerative Colitis: Defining Variability in Practice, Risk Factors, and Patient-Centered Outcomes
Given the increasing prevalence and significant morbidity of pediatric ulcerative colitis (UC), it is imperative that we understand and define all knowledge gaps related to this disease. Adult data suggest that despite improved outcomes with newer medications, surgical outcomes have…
Opioid Prescribing Disparities in a Public Health Crisis: The Case of Pediatric Post-Surgical Pain Management
Abstract African Americans adults are less likely to receive analgesics, particularly opioids, even after controlling for pain severity. Research in the pediatric surgical population is more limited but the pattern of disparate use of opioids appear consistent with adult research….
Development of Brief Screening Algorithm for Early Identification of VWD in Women (Developing Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease)
Bleeding disorders in women are an under-recognized and under-treated condition, and von Willebrand Disease (VWD) is the most common bleeding disorder diagnosed in women. This study will develop a screening algorithm for VWD that incorporates a brief bleeding history and…
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