PEDSnet and the AR2 Center will collaborate to enable model validation and replication activities using pediatric data. The focus is on leveraging existing data within PEDSnet’s Common Data Model (CDM) to support independent validation of models and methods developed under Tasks I-III of the NIH Autism Data Science Initiative (ADSI) This study aims to refine […]
Obesity is a common, pervasive, chronic disease often beginning in early childhood, and infant growth characteristics are key signals of lifelong chronic disease risk. Frequent primary care visits in the first two years of life provide many opportunities for growth surveillance and early intervention, but there are no current clinical practice guidelines for identifying infant […]
One in four children experience chronic pain worldwide. Primary chronic pain is the most common type of chronic pain in childhood and is associated with negative impact on physical, psychological, and social functioning. Many children have mental health symptoms (e.g., anxiety, depression, insomnia) which impact on their pain experience and are associated with poor prognosis. […]
Five-year relative survival rates for Hodgkin lymphoma (HL) are excellent at ~90%, yet Black and Hispanic patients have worse survival outcomes than White patients across all age groups (children, young adults, and older adults). HL’s age distribution and generally high cure rates offer a paradigm to study cancer inequities across the lifespan, since each age […]
The purpose of this study is to understand the effects of parathyroid hormone levels on risks of skeletal fractures among children with chronic kidney disease. Investigators will utilize the existing row-level PEDSnet dataset previously created to examine the effects of phosphate binder use on rates of skeletal fractures in children with CKD. This dataset contains […]
Children with chronic kidney disease (CKD) have higher rates of hospitalizations, metabolic abnormalities, cardiovascular disease, and growth restriction, compared to their healthy counterparts. 1-4 Growth failure is common in pediatric CKD; affecting up to 35% of these children. 5 Children with kidney failure and short stature have increased mortality risk compared to those children with […]
The purpose of our study is to evaluate the long-term outcomes after AKI in critically ill children and identify the risk factors associated with these outcomes. Our central hypothesis is that long-term major adverse kidney events (MAKE; a composite of death, dialysis dependence or persistent kidney dysfunction) is common after AKI in critically ill patients, […]
Pseudohypoaldosteronism can be a potentially fatal disease involving a disruption in the mineralocorticoid aldosterone. Given aldosterone’s role in maintaining fluid homeostasis, an imbalance results in hypokalemia, hypernatremia, and metabolic acidosis in newborns. The clinical presentation of pseudohypoaldosteronism mirrors congential adrenal hyperplasia (CAH), often resulting in a misdiagnosis and delayed treatment of PHA. We hope to […]
Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) that affect approximately 1.2 million individuals in the United States, cost over $6 billion annually, and cause substantial patient morbidity, missed work and school, and diminished quality of life. Pediatric onset IBD (PIBD) is a distinct entity, often presenting with more severe […]
Although language disparities in outcomes are well documented in general pediatrics and adult oncology, little is known in pediatric oncology. Patient or family language is not included in many multi- institutional databases and patient registries, limiting studies of language-based inequities to single institutions. It is essential to identify specific disparities in outcomes to start building […]