Pseudohypoaldosteronism can be a potentially fatal disease involving a disruption in the mineralocorticoid aldosterone. Given aldosterone’s role in maintaining fluid homeostasis, an imbalance results in hypokalemia, hypernatremia, and metabolic acidosis in newborns. The clinical presentation of pseudohypoaldosteronism mirrors congential adrenal hyperplasia (CAH), often resulting in a misdiagnosis and delayed treatment of PHA. We hope to learn not only more about long-term outcomes of children diagnosed with PHA in addition to the potential impact a misdiagnosis of CAH has on clinical course.
Distinguishing clinical manifestations, treatment, and long-term outcomes of pseudohypoaldosteronism (PHA) vs congenital adrenal hyperplasia (CAH)
Funding Source:
Participating PEDSnet Sites:
- Ann & Robert H. Lurie Children’s Hospital of Chicago
- Children’s Hospital Colorado
- Children’s National Hospital
- Children’s Hospital of Philadelphia
- Cincinnati Children’s Hospital Medical Center
- Nationwide Children’s Hospital
- Nemours Children’s Health
- Seattle Children’s Hospital
- Stanford Children’s Health
- Texas Children’s Hospital
Study Investigator:
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