Pediatric Chron’s Disease (PCD) is a chronic inflammatory bowel disease (IBD) that has been recognized as one of the most important chronic diseases that affect children and adolescents, with increasing incidence in youth of varying ages. Literature presents gaps in understanding how to synthesize partial or pieces of evidence from multiple sites using distributed analysis for comparison of multiple treatments with respect to multiple patient-centered outcomes and how to better identify covariates that contribute to heterogeneous treatment effect (HTE) using data from distributed research networks (DRN).
In this study, the research team is to develop evidence synthesis methods to improve distributed analyses in DRN and to advance understanding of the benefits and risks of different treatment options. The proposed methods aim to expand the scope and patient-centeredness of research using data from clinical data research networks (CDRNs).