Cohort Attrition Study Results Part III: SSDQA Comparison


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2025-10
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PEDSnet

Abstract

The results of a Cohort Attrition check using the Multi-Site, Exploratory, Cross-Sectional parameters. This check investigates the patient retention at each step of the attrition, after adjustments were made to the attrition criteria to remove the need for parsing lab result values.

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PEDSnet Data Coordinating Center

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Description

  • The previous round of data quality analysis revealed that the issue with two sites dropping out of the cohort was likely due to the lab result parsing rather than the presence of labs in the first place. The attrition criteria was adjusted to only require that an SCD lab have been conducted, rather than also requiring a positive result. This was deemed acceptable because of the existing diagnosis requirement ensuring that all patients would have been formally diagnosed with SCD, regardless of the results of their labs.
  • Cohort size increased overall across all institutions. There still appears to be a notable drop off between steps 3 and 4 despite the adjusted lab requirement.
  • CCHMC & Stanford now have patients present in the cohort, although the counts are still relatively small. This may be due to the demographic makeup of these institutions rather than indicative of a data quality issue, but we will conduct further analysis to be sure.

Response to Findings

The results of this attrition are more aligned with expectations compared to the previous two attrition results. We will conduct some additional data quality analysis to ensure that fact density and the presence of key variables is still in line with study needs based on this updated cohort.

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Data Source

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PEDSnet Production Database (2025-04)
Created:2025-04Affiliation:PEDSnet Data Coordinating Center
PEDSnet production database containing de-identified aggregate electronic healthcare information for ten contributing pediatric healthcare institutions. This database corresponds to Version 5.7 of the PEDSnet data model.

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Institutions

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Nationwide Children's Hospital
Nationwide Children’s Hospital (NCH) is a 508-bed hospital with over 18,000 admissions and 1.2 million outpatient visits annually. It also performs nearly 10,000 inpatient and over 17,000 outpatient surgeries annually. Care is provided at 62 sites largely concentrated in central Ohio. NCH operates 15 wholly owned primary care sites that serve 75,000 unique children and adolescents as their medical home. In addition, NCH operates Urgent Care Centers and one of the largest ED’s in the US totaling 250,000 visits per year. NCH also operates the largest pediatric outpatient service at a children’s hospital in the US with more than 180,000 visits per year. All of these sites have been used for research enrollment as have others. NCH’s ChildLab is the largest provider of pediatric labs in the state and operates at numerous sites both in central Ohio and southern and eastern parts of the state. ChildLab has partnered on other research studies. Finally, NCH is also home to Partners for Kids, the largest and oldest pediatric Accountable Care Organization in the US exclusively for children. Partners for Kids has been committed to enrolling patients in research to improve care since its inception and currently is home to a PCORI award and an NIMH contract focused on quality improvement.
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Children's Hospital Colorado
Children’s Hospital Colorado (Children’s Colorado) has defined and delivered pediatric health care excellence for more than 100 years. Founded in 1908, Children’s Colorado is a leading pediatric network entirely devoted to the health and well-being of children. Continually acknowledged as one of the nation’s outstanding pediatric hospitals by U.S. News & World Report and ranked 5th on its Best Children’s Hospitals 2015-16 Honor Roll, Children’s Colorado is known for both its nationally and internationally recognized medical, research, education and advocacy programs, as well as comprehensive everyday care for kids throughout Colorado and surrounding states. Children’s Colorado is the winner of the 2015 American Hospital Association-McKesson Quest for Quality Prize, and is a 2015 Most Wired hospital according to Hospitals & Health Networks magazine. Children’s Colorado also is recognized for excellence in nursing from the American Nurses Credentialing Centers and has been designated a Magnet® hospital since 2005. The hospital’s family-centered, collaborative approach combines the nation’s top pediatric doctors, nurses and researchers to pioneer new approaches to pediatric medicine. With urgent, emergency and specialty care locations throughout Metro Denver and Southern Colorado, including its campus on the Anschutz Medical Campus, Children’s Colorado provides a full spectrum of pediatric specialties.
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Seattle Children's Hospital
Seattle Children’s Hospital is the pediatric and adolescent referral center for Washington, Alaska, Montana and Idaho, serving the Pacific Northwest region since it was founded in 1907 and delivering superior patient care and advanced new treatments through pediatric research. We have over 300,000 outpatient visits per year taking place within a robust clinical program serving local Seattle residents as well as 21 regional clinics across three states. Our main campus has over 15,000 inpatient admissions annually and our state of the art Emergency Department, newly opened in 2013, has over 37,000 visits per year. We are the first hospital in the country to open a teen and young adult inpatient cancer unit dedicated to serving the needs of this unique population and housing the Children’s Adolescent and Young Adult Oncology Program. We are also the primary teaching, clinical and research site for the Department of Pediatrics at the University of Washington School of Medicine, training approximately 900 residents and fellows and 750 medical students annually. Our affiliated Research Institute consistently ranks in the top five for pediatric research funding from the National Institutes of Health and our Foundation partners have helped raise over $120,000,000 for our uncompensated/undercompensated care fund ensuring we never had to turn away a child in need.
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Children's National Hospital
Serving the nation’s children for more than 150 years, Children’s National Hospital has been an innovator in pediatric health care around the nation and around the world. Children’s National was one of the nation’s first children’s hospitals, opening in 1870 and growing from a modest 12-bed facility to a 323-bed facility that performs more than 17,000 surgeries and conducts more than 669,000 outpatient visits in more than 60 specialties each year. Formerly referred to as D.C. Children’s Hospital, Children’s National is the only exclusive provider of pediatric care in the Washington, D.C., metropolitan area. Today, the health system includes primary care health centers, regional outpatient centers, and affiliated pediatric primary and specialty care practices throughout the metropolitan area, in addition to providing tertiary care in our main hospital.
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Ann & Robert H. Lurie Children's Hospital of Chicago
Lurie Children's works to provide the best possible care for patients and their families. More than 239,000 children receive the highest-quality medical care at Lurie Children’s each year. Lurie Children’s treats more children insured by Medicaid than any other hospital in Illinois.

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a CC-BY Attribution 4.0 license.
Except where otherwised noted, this item's license is described as a CC-BY Attribution 4.0 license.

Cite this Data Quality Result

Wieand, K. (2025, September). Cohort Attrition Study Results Part III: SSDQA Comparison. [D Q Result]. PEDSpace Knowledge Bank. https://hdl.handle.net/20.500.14642/1225.3

Version History

Now showing 1 - 2 of 2
VersionDateSummary
4
 2026-02-25 14:29:03
Fourth round of cohort attrition conducted after after an additional attrition step was added requiring 2 or more Sickle Cell Anemia (SCA) diagnoses for each patient.
3*
 2025-12-19 11:47:51
Third round of cohort attrition conducted after adjustments were made to the attrition criteria to remove the need for parsing lab result values.
* Selected version