Childhood Neighborhood Exposures and Pediatric Multiple Sclerosis
Question 1: How can we identify children with MS using ICD-10 codes in the PEDSnet dataset Question 2: How do neighborhood exposures influence the risk of pediatric MS development Aim 1: Validate a computable phenotype to identify pediatric MS. Aim…
Preventing Suicide among Sexual and Gender Diverse Youth
Suicide is the second leading cause of death among young adults in the United States. Sexual and gender diverse young adults (SGDYA) are at particularly high risk. SGDYA includes individuals who are lesbian, gay, bisexual, transgender, queer, or of another…
Identifying Pediatric Pancreatitis and Predicting Pancreatic Diabetes (T3cD)
Type 3c diabetes (T3cD) is a distinct form of diabetes related to diseases of the exocrine pancreas. In the setting of pancreatitis, T3cD affects 4-9% of children and is associated with long-term morbidity and increased mortality. T3cD is understudied especially…
AR2 (Autism Replication & Reproducibility) Center – NIH Autism Data Science Initiative Task 4 Application
PEDSnet and the AR2 Center will collaborate to enable model validation and replication activities using pediatric data. The focus is on leveraging existing data within PEDSnet’s Common Data Model (CDM) to support independent validation of models and methods developed under…
Distinguishing clinical manifestations, treatment, and long-term outcomes of pseudohypoaldosteronism (PHA) vs congenital adrenal hyperplasia (CAH)
Pseudohypoaldosteronism can be a potentially fatal disease involving a disruption in the mineralocorticoid aldosterone. Given aldosterone’s role in maintaining fluid homeostasis, an imbalance results in hypokalemia, hypernatremia, and metabolic acidosis in newborns. The clinical presentation of pseudohypoaldosteronism mirrors congential adrenal…
Creation of Computable Alopecia Areata Phenotype to Evaluate Epidemiology of Pediatric Alopecia Areata and Potential Health Care Disparities in care among children living with Alopecia Areata
Alopecia areata is a chronic, T-cell-mediated disease that targets hair follicles and causes patches of nonscarring hair loss. Despite being relatively common (prevalence of 1-2%), current studies on alopecia areata epidemiology are conflicting, and no large-scale epidemiologic studies have been…
Opioid Prescribing Disparities in a Public Health Crisis: The Case of Pediatric Post-Surgical Pain Management
Abstract African Americans adults are less likely to receive analgesics, particularly opioids, even after controlling for pain severity. Research in the pediatric surgical population is more limited but the pattern of disparate use of opioids appear consistent with adult research….
Anti-TNF Monotherapy versus Combination Therapy with Low Dose Methotrexate in Pediatric Crohn’s Disease (The COMBINE Study)
Crohn’s disease causes inflammation in the intestines and stomach, leading to long-term diarrhea and stomach pain. It can also lead to growth problems and lower quality of life. For children, the illness can get worse over time.Doctors treat Crohn’s disease…
Unanticipated Consequences of Proton Pump Inhibitor Use
This study investigates whether genetic variation in CYP2C19 contributes to proton pump inhibitor-associated infections and chronic illness exacerbations in children. Study aims include: 1) To compare rates of infection in healthy and obese children, and children with chronic illnesses of…
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