Chronic Kidney Disease (CKD) Etiology
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Phenotype Description
A function for identifying and categorizing chronic kidney disease (CKD) etiologies in a given cohort of patients.
Downloadable content for this Phenotype includes two R files (cohorts.R and driver.R) and a specs folder, which includes the related concept sets linked below.
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Provenance
Developed as part of the Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) study.
Algothrithm Description
This function will categorize each patient in a provided cohort into one of several different etiology groupings based on their CKD status and characterization. There are three different hierarchies available for classification:
- A 2-factor hierarchy classifying patients into glomerular or non-glomerular status;
- a 3-factor hierarchy classifying patients into malignant, glomerular disease, or other status;
- and a 4-factor hierarchy classifying patients into malignant, glomerular disease, other kidney disease, or other/non-specific statuses.
The malignant and glomerular disease statuses are identified using their associated phenotypes, while the “other kidney disease” status is identified using a concept set.
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Creative Commons license
Except where otherwised noted, this item's license is described as a CC-BY Attribution 4.0 license.
Cite this Phenotype
Wieand, K. (2025, January). Chronic Kidney Disease (CKD) Etiology. [Phenotype]. PEDSpace Knowledge Bank. https://doi.org/10.24373/pdsp-8